| Title: | Sensory eye irritation in humans exposed to mixtures of volatile organic compounds |
| Author(s): | Hempel-Jorgensen A; Kjaergaard SK; Molhave L; Hudnell KH; |
| Address: | "Department of Environmental and Occupational Medicine, University of Aarhus, Denmark" |
| DOI: | 10.1080/00039899909603373 |
| ISSN/ISBN: | 0003-9896 (Print) 0003-9896 (Linking) |
| Abstract: | "Eight subjects participated in a controlled eyes-only exposure study of human sensory irritation in ocular mucosal tissue. The authors investigated dose-response properties and the additive effects of three mixtures of volatile organic compounds. The dose-response relationships for these mixtures showed increases in response intensity as concentration increased. Replication of exposure did not result in significantly different dose- response relationships. Moreover, the result implied that components of the three mixtures interacted additively to produce ocular irritation, a result referred to as simple agonism. Finally, the authors addressed the comparability of two methods to measure sensory irritation intensity (visual analogue scale and a comparative scale). The results indicated that the two rating methods produced highly comparable results" |
| Keywords: | "Adult Air Pollutants/adverse effects Data Interpretation, Statistical Dose-Response Relationship, Drug Eye/*drug effects Female Humans Irritants/administration & dosage/*adverse effects Male Middle Aged Organic Chemicals/administration & dosage/*adverse e;" |
| Notes: | "MedlineHempel-Jorgensen, A Kjaergaard, S K Molhave, L Hudnell, K H eng Comparative Study Research Support, U.S. Gov't, Non-P.H.S. 2000/01/14 Arch Environ Health. 1999 Nov-Dec; 54(6):416-24. doi: 10.1080/00039899909603373" |
