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Toxicol Sci

Title:		Quantitative structure-activity relationships for nasal pungency thresholds of volatile organic compounds
Author(s):		Hau KM; Connell DW; Richardson BJ;
Address:		"Health and Safety Office, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong"
Journal Title:		Toxicol Sci
Year:		1999
Volume:		47
Issue:		1
Page Number:		93 - 98
DOI:		10.1093/toxsci/47.1.93
ISSN/ISBN:		1096-6080 (Print) 1096-0929 (Linking)
Abstract:		"A model was developed for describing the triggering of nasal pungency in humans, based on the partition of volatile organic compounds (VOCs) between the air phase and the biophase. Two partition parameters are used in the model: the water-air partition coefficient and the octanol-water partition coefficient. The model was validated using data from the literature, principally on alcohols, acetates and ketones. The model suggests that all test compounds, regardless of their chemical functional groups, bind to a common receptor site within the hydrophobic interior of the bilayer membrane of the trigeminal nerve endings. There is probably only a slight, non-specific interaction between the VOC molecule and the receptor molecule, whereas this type of non-specific interaction for the detection of odor is much stronger. In practical terms, the suggestion that all VOCs share a common irritation receptor site implies that nasal-pungency thresholds of individual VOCs may be additive. Quantitative structure-activity relationships (QSARs) for nasal-pungency thresholds were also developed from the model, which can be used to predict nasal-pungency thresholds of common VOCs. Although the present model does not offer additional precision over that of M.H. Abraham et al., 1996, Fundam. Appl. Toxicol. 31, 71-76, it requires fewer descriptors and offers a physiological basis to the QSAR. Another advantage of the present model is that it also provides a basis for comparison between the olfactory process and nasal pungency"
Keywords:		"Air Pollutants/*chemistry/metabolism/toxicity Chemoreceptor Cells/metabolism Humans Irritants/*chemistry/metabolism/toxicity *Models, Biological Odorants Organic Chemicals/*chemistry/metabolism/toxicity Reproducibility of Results Sensory Thresholds *Smell;"
Notes:		"MedlineHau, K M Connell, D W Richardson, B J eng 1999/02/27 Toxicol Sci. 1999 Jan; 47(1):93-8. doi: 10.1093/toxsci/47.1.93"