| Title: | Volatile Organic Compounds to Identify Infectious (Bacteria/Viruses) Diseases of the Central Nervous System: A Pilot Study |
| Author(s): | Guo L; Qiu Z; Wang Y; Yu K; Zheng X; Li Y; Liu M; Wang G; Guo N; Yang M; Li E; Wang C; |
| Address: | "Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, China. Department of Anesthesiology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China" |
| ISSN/ISBN: | 1421-9913 (Electronic) 0014-3022 (Linking) |
| Abstract: | "BACKGROUND: Central nervous system (CNS) infectious diseases are common diseases in emergency rooms and neurology departments. CNS pathogen identification methods are time consuming and expensive and have low sensitivity and poor specificity. Some studies have shown that bacteria and viruses can produce specific volatile organic compounds (VOCs). The aim of this study is to find potential biomarkers by VOC analysis of cerebrospinal fluid (CSF) in patients with bacterial and viral meningitis/encephalitis (ME). METHODS: CSF samples from 16 patients with bacterial ME and 42 patients with viral ME were collected, and solid-phase microextraction combined with gas chromatography-mass spectrometry was used to analyze the metabolites in the CSF. RESULTS: There are 2 substances (ethylene oxide and phenol) that were found to be different between the 2 groups. Ethylene oxide was significantly greater in the group of bacterial ME patients than in the viral ME group of patients (p < 0.05). In addition, phenol was remarkably increased in the group of ME patients compared with the bacterial ME patients (p < 0.05). CONCLUSIONS: Ethylene oxide and phenol may be potential biomarkers to distinguish bacterial ME and viral ME. VOC analysis of CSF may be used as a supporting tool for clinical diagnosis" |
| Keywords: | "Bacteria Central Nervous System *Communicable Diseases Humans *Meningitis, Bacterial Pilot Projects *Viruses *Volatile Organic Compounds Bacterial meningitis/encephalitis Biomarkers Central nervous system infectious diseases Viral meningitis/encephalitis;" |
| Notes: | "MedlineGuo, Lei Qiu, Zhongzhi Wang, Yue Yu, Kaili Zheng, Xiaoya Li, Yuhang Liu, Miao Wang, Guiyue Guo, Nana Yang, Mengyuan Li, Enyou Wang, Changsong eng Research Support, Non-U.S. Gov't Switzerland 2021/06/29 Eur Neurol. 2021; 84(5):325-332. doi: 10.1159/000507188. Epub 2021 Jun 28" |
