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Integr Zool

Title:		Social dominance-related major urinary proteins and the regulatory mechanism in mice
Author(s):		Guo H; Fang Q; Huo Y; Zhang Y; Zhang J;
Address:		"State Key Laboratory of Integrated Management of Pest Insects and Rodents in Agriculture, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"
Journal Title:		Integr Zool
Year:		2015
Volume:		10
Issue:		6
Page Number:		543 - 554
DOI:		10.1111/1749-4877.12165
ISSN/ISBN:		1749-4877 (Electronic) 1749-4869 (Linking)
Abstract:		"Major urinary proteins (MUPs) have been proven to be non-volatile male pheromones in mice. Here, we aimed to elucidate the relationship between MUPs and dominance hierarchy, and the underlying molecular mechanisms. Dominance-submission relationship was established by chronic dyadic encountering. We found that at the urinary protein level and hepatic mRNA level, the expression of major MUPs, including Mup20, was enhanced in dominant males compared with subordinate males, indicating that MUPs might signal the social status of male mice. Meanwhile, the mRNA level of hepatic corticotropin releasing hormone receptor 2 (CRHR2) was higher in subordinate male mice than in dominant male mice. Castration also enhanced the expression of CRHR2, but suppressed that of MUPs. CRHR2 agonist treatment reduced the expression of MUPs in liver. However, male social status failed to exert significant influence on serum testosterone and corticosterone as well as the mRNA expression of their receptors. These findings reveal that some MUPs, especially Mup20, might constitute potential dominance pheromones and could be downregulated by hepatic CRHR2, which is possibly independent of androgen or corticosterone systems"
Keywords:		"Animals Castration Corticosterone/blood Liver/*metabolism Male Mice Pheromones/metabolism Proteins/*metabolism RNA, Messenger/metabolism Receptors, Corticotropin-Releasing Hormone/*metabolism *Social Dominance Testosterone/blood androgen corticosterone co;"
Notes:		"MedlineGuo, Huifen Fang, Qi Huo, Ying Zhang, Yaohua Zhang, Jianxu eng Research Support, Non-U.S. Gov't Australia 2015/09/04 Integr Zool. 2015 Nov; 10(6):543-54. doi: 10.1111/1749-4877.12165"