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Science

Title:		Role of type I myosins in receptor-mediated endocytosis in yeast
Author(s):		Geli MI; Riezman H;
Address:		"Department of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, Switzerland"
Journal Title:		Science
Year:		1996
Volume:		272
Issue:		5261
Page Number:		533 - 535
DOI:		10.1126/science.272.5261.533
ISSN/ISBN:		0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"Type I myosins are thought to drive actin-dependent membrane motility, but the direct demonstration in vivo of their involvement in specific cellular processes has been difficult. Deletion of the genes MYO3 and MYO5, which encode the yeast type I myosins, almost abolished growth. A double-deleted mutant complemented with a MYO5 temperature-sensitive allele (myo5-1) showed a strong defect in the internalization step of receptor-mediated endocytosis, whereas the secretory pathway remained apparently unaffected. Thus, myosin I activity is required for a budding event in endocytosis but not for several other aspects of membrane traffic"
Keywords:		"Alleles Endocytosis/*physiology Gene Deletion Mating Factor Molecular Sequence Data Mutation Myosins/genetics/*physiology Peptides/metabolism Receptors, Mating Factor Receptors, Peptide/metabolism Saccharomyces cerevisiae/genetics/*physiology Temperature;"
Notes:		"MedlineGeli, M I Riezman, H eng Research Support, Non-U.S. Gov't 1996/04/26 Science. 1996 Apr 26; 272(5261):533-5. doi: 10.1126/science.272.5261.533"