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Ann Biol Clin (Paris)

Title:		[Pheromones: an underestimated communication signal in humans]
Author(s):		Frey J;
Address:		jacfrey@free.fr
Journal Title:		Ann Biol Clin (Paris)
Year:		2003
Volume:		61
Issue:		3
Page Number:		275 - 278
DOI:
ISSN/ISBN:		0003-3898 (Print) 0003-3898 (Linking)
Abstract:		"The pheromones are molecules, mainly aliphatic acids, with or without perceptible odor, recognized by specific receptors, the stimulation of which induces neuroendocrine reactions and affects the individual behavior. Olfactory receptors are underexpressed in human, 70 % of genes have become nonfunctional pseudogenes. But the remaining function was tested and is able to induce emotional reactions corresponding to a non-verbal signal of social interactions. In the present study, we review the actual knowledge on the olfactory receptors. They belong to the G-protein-coupled-receptors. Their signal is transduced to the hypothalamic-pituitary-gonadal axis. Some HLA-based olfactory cues are shown with reference to recent experiments. The pathophysiological hypotheses are considered with respect to studies in anorexia nervosa and Alzheimer' disease"
Keywords:		Animals Communication Emotions/physiology GTP-Binding Proteins/physiology HLA Antigens/physiology Humans Hypothalamo-Hypophyseal System/physiology Neurosecretory Systems/drug effects/physiology Nonverbal Communication/*physiology Olfactory Pathways Olfact;
Notes:		"MedlineFrey, J fre English Abstract Review France 2003/06/14 Ann Biol Clin (Paris). 2003 May-Jun; 61(3):275-8"