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Sci STKE

Title:		What do scaffold proteins really do?
Author(s):		Ferrell JE;
Address:		"Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA, USA. ferrell@cmgm.stanford.edu"
Journal Title:		Sci STKE
Year:		2000
Volume:		20001003
Issue:		52
Page Number:		e1 -
DOI:		10.1126/stke.2000.52.pe1
ISSN/ISBN:		1525-8882 (Electronic) 1525-8882 (Linking)
Abstract:		"Scaffold proteins play an important role in coordinating signal transduction cascades. However, their exact mechanism of action and the ultimate effect they have on the signal output remain unclear. Ferrell discusses how computer simulations have provided insight into the multiple possible functions that scaffold proteins may have. What remains is to test the predictions in real cells to determine what difference the presence of a scaffold really makes in the output of a signaling pathway"
Keywords:		Animals MAP Kinase Signaling System/physiology Pheromones/physiology Saccharomyces cerevisiae/chemistry/enzymology Saccharomyces cerevisiae Proteins/*physiology Signal Transduction/*physiology;
Notes:		"MedlineFerrell, J E Jr eng Review 2001/12/26 Sci STKE. 2000 Oct 3; 2000(52):pe1. doi: 10.1126/stke.2000.52.pe1"