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Cell

Title:		A position effect on the time of replication origin activation in yeast
Author(s):		Ferguson BM; Fangman WL;
Address:		"Department of Genetics, University of Washington, Seattle 98195"
Journal Title:		Cell
Year:		1992
Volume:		68
Issue:		2
Page Number:		333 - 339
DOI:		10.1016/0092-8674(92)90474-q
ISSN/ISBN:		0092-8674 (Print) 0092-8674 (Linking)
Abstract:		"The chromosomes of eukaryotes are characterized by the mosaic nature of their replication--large regions of DNA that replicate early in S phase are interspersed with regions that replicate late. This pattern of early and late synthesis appears to be the consequence of a temporal program that activates replication origins at different times. The basis of this temporal regulation in the yeast S. cerevisiae has been investigated by changing the chromosomal locations of two origins, one activated early in the S phase (ARS1) and one activated late (ARS501). We show that the cis-acting information controlling time of activation can be separated from the element that determines origin function. For the ARS501 origin, late activation appears to be a consequence of its proximity to the telomere"
Keywords:		"Chromosomes, Fungal/physiology DNA Replication/*genetics DNA, Fungal/*genetics/metabolism Kinetics Mating Factor Peptides/metabolism Plasmids/genetics Regulatory Sequences, Nucleic Acid/*genetics Saccharomyces cerevisiae/*genetics Telomere/physiology;"
Notes:		"MedlineFerguson, B M Fangman, W L eng GM18926/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1992/01/24 Cell. 1992 Jan 24; 68(2):333-9. doi: 10.1016/0092-8674(92)90474-q"