| Title: | Synthesis and biological evaluation of 1-amino isochromans from 2-bromoethyl benzaldehyde and amines in acid medium |
| Author(s): | Fatima N; Reddy BVS; Gowravaram S; Yadav JS; Kadari S; Putta CS; |
| Address: | "Center for Semiochemicals Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: dr.narjisiict@yahoo.com. Center for Semiochemicals Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. Osmania University, Hyderabad 500 607, India" |
| DOI: | 10.1016/j.bmcl.2017.11.020 |
| ISSN/ISBN: | 1464-3405 (Electronic) 0960-894X (Linking) |
| Abstract: | "We have developed a facile and efficient synthetic route to substituted isochromans for the first time by reacting 2-(2-bromoethyl)benzaldehyde with a variety of aryl, heteroaryl amines in AcOH. The reaction is catalyst/additive free and takes place at reflux conditions with short reaction time to furnish products in good to excellent yields. All the compounds have been characterized by spectral techniques such as IR, (1)H NMR and Mass etc. Synthesized compounds were evaluated for antimicrobial activity against specific bacterial like 1) Staphylococcus strains aureus 2) Bacillus subtilis 3) Escherichia coli 4) Pseudomonas aeruginosa. Compounds 3e, 3n, 3?ª+m, 3?ª+l, 3?ª+k, 3j and 3b showed most potent in vitro activity against bacterial strains" |
| Keywords: | Acetic Acid/*chemistry Amines/*chemistry Anti-Bacterial Agents/chemical synthesis/chemistry/*pharmacology Bacillus subtilis/drug effects Benzaldehydes/chemical synthesis/*chemistry Chromans/chemical synthesis/chemistry/*pharmacology Dose-Response Relation; |
| Notes: | "MedlineFatima, Narjis Reddy, B V Subba Gowravaram, Sabitha Yadav, J S Kadari, Sudhakar Putta, Chandra Shekar eng Research Support, Non-U.S. Gov't England 2017/12/05 Bioorg Med Chem Lett. 2018 Jan 15; 28(2):196-201. doi: 10.1016/j.bmcl.2017.11.020. Epub 2017 Nov 14" |
