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Curr Res Parasitol Vector Borne Dis

Title:		Variability in human attractiveness to mosquitoes
Author(s):		Ellwanger JH; Cardoso JDC; Chies JAB;
Address:		"Laboratorio de Imunobiologia e Imunogenetica, Programa de Pos-Graduacao em Genetica e Biologia Molecular - PPGBM, Departamento de Genetica, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Rio Grande do Sul, Brazil. Divisao de Vigilancia Ambiental em Saude, Centro Estadual de Vigilancia em Saude, Secretaria da Saude do Estado do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil"
Journal Title:		Curr Res Parasitol Vector Borne Dis
Year:		2021
Volume:		20211102
Issue:
Page Number:		100058 -
DOI:		10.1016/j.crpvbd.2021.100058
ISSN/ISBN:		2667-114X (Electronic) 2667-114X (Linking)
Abstract:		"Blood-feeding mosquitoes locate humans spatially by detecting a combination of human-derived chemical signals, including carbon dioxide, lactic acid, and other volatile organic compounds. Mosquitoes use these signals to differentiate humans from other animals. Spatial abiotic factors (e.g. humidity, heat) are also used by mosquitoes to find a host. Mosquitoes cause discomfort and harm to humans, being vectors of many pathogens. However, not all humans suffer from mosquito bites with the same frequency or intensity. Some individuals are more attractive to mosquitoes than others, and this has an important impact on the risk of infection by pathogens transmitted by these vectors, such as arboviruses and malaria parasites. Variability in human attractiveness to mosquitoes is partially due to individual characteristics in the composition and intensity in the release of mosquito attractants. The factors that determine these particularities are diverse, modestly understood and still quite controversial. Thus, this review discusses the role of pregnancy, infection with malaria parasites (Plasmodium spp.), skin microbiota, diet, and genetics in human attractiveness to mosquitoes. In brief, pregnancy and Plasmodium infection increase the host attractiveness to mosquitoes. Skin microbiota and human genetics (especially HLA alleles) modulate the production of mosquito attractants and therefore influence individual susceptibility to these insects. There is evidence pointing to a role of diet on human susceptibility to mosquitoes, with some dietary components having a bigger influence than others. In the last part of the review, other factors affecting human-mosquito interactions are debated, with a special focus on the role of mosquito genetics, pathogens and environmental factors (e.g. wind, environmental disturbances). This work highlights that individual susceptibility to mosquitoes is composed of interactions of different human-associated components, environmental factors, and mosquito characteristics. Understanding the importance of these factors, and how they interact with each other, is essential for the development of better mosquito control strategies and studies focused on infectious disease dynamics"
Keywords:		Animals;Culicidae Genetics Human attractiveness Microbiota Mosquito Mosquito bites;
Notes:		"PubMed-not-MEDLINEEllwanger, Joel Henrique Cardoso, Jader da Cruz Chies, Jose Artur Bogo eng Review Netherlands 2022/03/15 Curr Res Parasitol Vector Borne Dis. 2021 Nov 2; 1:100058. doi: 10.1016/j.crpvbd.2021.100058. eCollection 2021"