| Title: | Simultaneous Assessment of Urinary and Fecal Volatile Organic Compound Analysis in De Novo Pediatric IBD |
| Author(s): | El Manouni El Hassani S; Bosch S; Lemmen JPM; Brizzio Brentar M; Ayada I; Wicaksono AN; Covington JA; Benninga MA; de Boer NKH; de Meij TGJ; |
| Address: | "Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Academic Medical Center, 1081 HV Amsterdam, The Netherlands. s.elmanounielhassani@amsterdamumc.nl. Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The Netherlands. s.elmanounielhassani@amsterdamumc.nl. Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. s.bosch1@amsterdamumc.nl. Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The Netherlands. Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The Netherlands. m.brizziobrentar@amsterdamumc.nl. School of Engineering, University of Warwick, Coventry CV4 7AL, UK. A.Wicaksono@warwick.ac.uk. School of Engineering, University of Warwick, Coventry CV4 7AL, UK. J.A.Covington@warwick.ac.uk. Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Academic Medical Center, 1081 HV Amsterdam, The Netherlands. m.a.benninga@amsterdamumc.nl. Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands" |
| ISSN/ISBN: | 1424-8220 (Electronic) 1424-8220 (Linking) |
| Abstract: | "Endoscopic evaluation is mandatory in establishing the diagnosis of pediatric inflammatory bowel disease (IBD), but unfortunately carries a high burden on patients. Volatile organic compounds (VOC) have been proposed as alternative, noninvasive diagnostic biomarkers for IBD. The current study aimed to assess and compare the potential of fecal and urinary VOC as diagnostic biomarkers for pediatric IBD in an intention-to-diagnose cohort. In this cohort study, patients aged 4-17 years, referred to the outpatient clinic of a tertiary referral center under suspicion of IBD, were eligible to participate. The diagnosis was established by endoscopic and histopathologic assessment, participants who did not meet the criteria of IBD were allocated to the control group. Participants were instructed to concurrently collect a fecal and urinary sample prior to bowel lavage. Samples were analyzed by means of gas chromatography-ion mobility spectrometry. In total, five ulcerative colitis patients, five Crohn's disease patients, and ten age and gender matched controls were included. A significant difference was demonstrated for both fecal (p-value, area under the curve; 0.038, 0.73) and urinary (0.028, 0.78) VOC profiles between IBD and controls. Analysis of both fecal and urinary VOC behold equal potential as noninvasive biomarkers for pediatric IBD diagnosis" |
| Keywords: | "Adolescent Biomarkers/urine Case-Control Studies Child Child, Preschool Colitis, Ulcerative/pathology/*urine Crohn Disease/pathology/*urine Feces/chemistry Female Gas Chromatography-Mass Spectrometry Humans Inflammatory Bowel Diseases/pathology/*urine Mal;" |
| Notes: | "MedlineEl Manouni El Hassani, Sofia Bosch, Sofie Lemmen, Jesse P M Brizzio Brentar, Marina Ayada, Ibrahim Wicaksono, Alfian N Covington, James A Benninga, Marc A de Boer, Nanne K H de Meij, Tim G J eng Switzerland 2019/10/19 Sensors (Basel). 2019 Oct 16; 19(20):4496. doi: 10.3390/s19204496" |
