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FEBS Lett


Title:The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole
Author(s):Egner R; Kuchler K;
Address:"Department of Molecular Genetics, University and Biocenter Vienna, Austria"
Journal Title:FEBS Lett
Year:1996
Volume:378
Issue:2
Page Number:177 - 181
DOI: 10.1016/0014-5793(95)01450-0
ISSN/ISBN:0014-5793 (Print) 0014-5793 (Linking)
Abstract:"We have recently demonstrated that the Pdr5 ATP binding cassette multidrug transporter is a short-lived protein, whose biogenesis involves cell surface targeting followed by endocytosis and delivery to the vacuole for proteolytic turnover [Egner, R., Mahe, Y., Pandjaitan, R., and Kuchler, K. (1995) Mol. Cell. Biol. 15, 5879-5887]. Using c-myc epitope-tagged ubiquitin, we now have shown that Pdr5 is a ubiquitinated plasma membrane protein in vivo. Ubiquitination of Pdr5 was detected in both wild type and conditional end mutants defective in endocytic vesicle formation. Likewise, the Ste6 a-factor pheromone transporter, which represents another short-lived ABC transporter whose turnover requires vacuolar proteolysis, was also found to be ubiquitinated, and ubiquitin-modified Ste6 massively accumulated in end4 mutants at the restrictive temperature. By contrast, the plasma membrane ATPase Pma1, a long-lived and metabolically very stable protein, was found not to be ubiquitinated. Our results imply a novel function for ubiquitin in protein trafficking and suggest that ubiquitination of certain short-lived plasma membrane proteins may trigger their endocytic delivery to the vacuole for proteolytic turnover"
Keywords:ATP-Binding Cassette Transporters/*metabolism Cell Membrane/chemistry *Endocytosis Fungal Proteins/*metabolism Hemagglutinins Membrane Proteins/*metabolism Saccharomyces cerevisiae/*chemistry *Saccharomyces cerevisiae Proteins Ubiquitins/*metabolism Vacuo;
Notes:"MedlineEgner, R Kuchler, K eng Research Support, Non-U.S. Gov't England 1996/01/08 FEBS Lett. 1996 Jan 8; 378(2):177-81. doi: 10.1016/0014-5793(95)01450-0"

 
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