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Gen Comp Endocrinol

Title:		"The transcription factor Kruppel homolog 1 is linked to the juvenile hormone-dependent maturation of sexual behavior in the male moth, Agrotis ipsilon"
Author(s):		Duportets L; Bozzolan F; Abrieux A; Maria A; Gadenne C; Debernard S;
Address:		"UMR 1272, UPMC-INRA, Physiologie de l'Insecte: Signalisation et Communication, Universite Paris VI, Batiment A, 7 quai Saint Bernard, 75005 Paris, France"
Journal Title:		Gen Comp Endocrinol
Year:		2012
Volume:		20120120
Issue:		2
Page Number:		158 - 166
DOI:		10.1016/j.ygcen.2012.01.005
ISSN/ISBN:		1095-6840 (Electronic) 0016-6480 (Linking)
Abstract:		"In the male moth, Agrotis ipsilon, the behavioral response and neuronal sensitivity in the primary olfactory center, the antennal lobe (AL), to sex pheromone increase with age and juvenile hormone (JH) biosynthesis. Although JH has been shown to control this age-dependent plasticity, the underlying signaling pathway remains obscure. In this context, we cloned a full cDNA encoding the Kruppel homolog 1 transcription factor (AipsKr-h1) of A. ipsilon, which was found to be predominantly expressed in ALs, where its amount increased concomitantly with age and sex pheromone responses. Conversely, the expression of AipsKr-h1 protein in the antenna was age-independent. Moreover, the administration of JH in immature males or fluvastatin, an inhibitor of JH biosynthesis, in mature males induced an increase or a decline of the AipsKr-h1 protein level in ALs, respectively. This effect was suppressed with a combined injection of fluvastatin and JH. Our results showed that Aipskr-h1 is a JH-upregulated gene that might mediate JH action on central pheromone processing, modulating sexual behavior in A. ipsilon"
Keywords:		"Animals Fatty Acids, Monounsaturated/pharmacology Fluvastatin Indoles/pharmacology Juvenile Hormones/*pharmacology Kruppel-Like Transcription Factors/*metabolism Male Moths/*metabolism/*physiology Sexual Behavior, Animal/*drug effects;"
Notes:		"MedlineDuportets, Line Bozzolan, Francoise Abrieux, Antoine Maria, Annick Gadenne, Christophe Debernard, Stephane eng Research Support, Non-U.S. Gov't 2012/01/31 Gen Comp Endocrinol. 2012 Apr 1; 176(2):158-66. doi: 10.1016/j.ygcen.2012.01.005. Epub 2012 Jan 20"