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J Pharm Biomed Anal

Title:		Using a portable ion mobility spectrometer to screen dietary supplements for sibutramine
Author(s):		Dunn JD; Gryniewicz-Ruzicka CM; Kauffman JF; Westenberger BJ; Buhse LF;
Address:		"Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, MO 63101, United States. Jamie.Dunn@fda.hhs.gov"
Journal Title:		J Pharm Biomed Anal
Year:		2011
Volume:		20100919
Issue:		3
Page Number:		469 - 474
DOI:		10.1016/j.jpba.2010.09.017
ISSN/ISBN:		1873-264X (Electronic) 0731-7085 (Linking)
Abstract:		"In response to recent incidents of undeclared sibutramine, an appetite suppressant found in dietary supplements, we developed a method to detect sibutramine using hand-held ion mobility spectrometers with an analysis time of 15 s. Ion mobility spectrometry is a high-throughput and sensitive technique that has been used for illicit drug, explosive, volatile organic compound and chemical warfare detection. We evaluated a hand-held ion mobility spectrometer as a tool for the analysis of supplement extracts containing sibutramine. The overall instrumental limit of detection of five portable ion mobility spectrometers was 2 ng of sibutramine HCl. When sample extractions containing 30 ng/mul or greater of sibutramine were analyzed, saturation of the ionization chamber of the spectrometer occurred and the instrument required more than three cleaning cycles to remove the drug. Hence, supplement samples suspected of containing sibutramine should be prepared at concentrations of 2-20 ng/mul. To obtain this target concentration range for products containing unknown amounts of sibutramine, we provided a simple sample preparation procedure, allowing the U.S. Food and Drug Administration or other agencies to screen products using the portable ion mobility spectrometer"
Keywords:		"Appetite Depressants/*analysis Caffeine/analysis Counterfeit Drugs/adverse effects/analysis Cyclobutanes/*analysis Dietary Supplements/adverse effects/*analysis Humans Humidity Ions/*analysis Spectrometry, Mass, Electrospray Ionization Spectrum Analysis/*;"
Notes:		"MedlineDunn, Jamie D Gryniewicz-Ruzicka, Connie M Kauffman, John F Westenberger, Benjamin J Buhse, Lucinda F eng Research Support, U.S. Gov't, P.H.S. England 2010/10/14 J Pharm Biomed Anal. 2011 Feb 20; 54(3):469-74. doi: 10.1016/j.jpba.2010.09.017. Epub 2010 Sep 19"