| Title: | Prenatal Hypoxia Impairs Olfactory Function in Postnatal Ontogeny in Rats |
| Author(s): | Dubrovskaya NM; Vasilev DS; Tumanova NL; Alekseeva OS; Nalivaeva NN; |
| Address: | "Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. GRID: grid.419730.8. ISNI: 0000 0004 0440 2269" |
| DOI: | 10.1007/s11055-022-01233-3 |
| ISSN/ISBN: | 1573-899X (Electronic) 0097-0549 (Print) 0097-0549 (Linking) |
| Abstract: | "Analysis of the age-related dynamics of olfactory behavior in the odor preference and food search testsshowed that all male Wistar rats, regardless of age, preferred valerian essential oil, whose components have the properties of pheromones in rodents, when given a selection of eight essential oils; young rats displayed better food-seeking results than adult and old animals. Acute prenatal hypoxia (PH) on E14 (7% O(2) for 3 h) led to impairment of the valerian odor preference at all ages studied and to decreased productivity of food searches. Neurodegenerative processes were seen in the piriform cortex after PH, with reductions in the number of neurons and increases in glial elements. We have previously observed these changes in the entorhinal cortex and hippocampus, but not in the olfactory bulbs. This suggests that PH-induced decreases in olfactory function in rats may result from impairments to the formation of the central elements of the analyzer during the first months of postnatal ontogeny" |
| Keywords: | food search neurodegeneration odor preference olfaction olfactory bulb piriform cortex postnatal ontogeny prenatal hypoxia; |
| Notes: | "PubMed-not-MEDLINEDubrovskaya, N M Vasilev, D S Tumanova, N L Alekseeva, O S Nalivaeva, N N eng 2022/03/24 Neurosci Behav Physiol. 2022; 52(2):262-270. doi: 10.1007/s11055-022-01233-3. Epub 2022 Mar 18" |
