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Biosensors (Basel)

Title:		Short-Term Effect of Cigarette Smoke on Exhaled Volatile Organic Compounds Profile Analyzed by an Electronic Nose
Author(s):		Dragonieri S; Quaranta VN; Buonamico E; Battisti C; Ranieri T; Carratu P; Carpagnano GE;
Address:		"Respiratory Diseases Unit, Department SMBNOS, University of Bari, 70121 Bari, Italy. Internal Medicine 'A.Murri', University of Bari, 70121 Bari, Italy"
Journal Title:		Biosensors (Basel)
Year:		2022
Volume:		20220713
Issue:		7
Page Number:		-
DOI:		10.3390/bios12070520
ISSN/ISBN:		2079-6374 (Electronic) 2079-6374 (Linking)
Abstract:		"Breath analysis using an electronic nose (e-nose) is an innovative tool for exhaled volatile organic compound (VOC) analysis, which has shown potential in several respiratory and systemic diseases. It is still unclear whether cigarette smoking can be considered a confounder when analyzing the VOC-profile. We aimed to assess whether an e-nose can discriminate exhaled breath before and after smoking at different time periods. We enrolled 24 healthy smokers and collected their exhaled breath as follows: (a) before smoking, (b) within 5 min after smoking, (c) within 30 min after smoking, and (d) within 60 min after smoking. Exhaled breath was collected by a previously validated method and analyzed by an e-nose (Cyranose 320). By principal component analysis, significant variations in the exhaled VOC profile were shown for principal component 1 and 2 before and after smoking. Significance was higher 30 and 60 min after smoking than 5 min after (p < 0.01 and <0.05, respectively). Canonical discriminant analysis confirmed the above findings (cross-validated values: baseline vs. 5 min = 64.6%, AUC = 0.833; baseline vs. 30 min = 83.6%, AUC = 0.927; baseline vs. 60 min = 89.6%, AUC = 0.933). Thus, the exhaled VOC profile is influenced by very recent smoking. Interestingly, the effect seems to be more closely linked to post-cigarette inflammation than the tobacco-related odorants"
Keywords:		*Cigarette Smoking Electronic Nose Exhalation Tobacco *Volatile Organic Compounds breath analysis smoking volatile organic compounds;
Notes:		"MedlineDragonieri, Silvano Quaranta, Vitaliano Nicola Buonamico, Enrico Battisti, Claudia Ranieri, Teresa Carratu, Pierluigi Carpagnano, Giovanna Elisiana eng Switzerland 2022/07/28 Biosensors (Basel). 2022 Jul 13; 12(7):520. doi: 10.3390/bios12070520"