| Title: | Thematic Minireview Series: Complexities of Cellular Signaling Revealed by Simple Model Organisms |
| Address: | "From the Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599-7260 hdohlman@asbmb.org" |
| ISSN/ISBN: | 1083-351X (Electronic) 0021-9258 (Print) 0021-9258 (Linking) |
| Abstract: | "All cells discriminate environmental signals and generate appropriate intracellular responses. Our understanding of these signal transduction mechanisms has benefitted from studies across the kingdoms of life, from fungi and fish to mice and men. This thematic minireview series examines lessons learned from three of the simplest (and best understood) eukaryotic model organisms. The first article focuses on the mating pheromone pathway in budding yeastSaccharomyces cerevisiae The second describes stress-mediated signaling in the roundwormCaenorhabditis elegans The third outlines some of the signaling pathways that dictate growth and development in the fruit flyDrosophila melanogaster Each system has provided unique insights into hormone and neurotransmitter signaling mechanisms, in particular those mediated by the MAPKs. The advances described in these articles will continue to improve our understanding of human physiology and pharmacology" |
| Keywords: | "Animals Caenorhabditis elegans/cytology/*physiology Drosophila melanogaster/cytology/*growth & development/metabolism Humans Mitogen-Activated Protein Kinases/metabolism Models, Animal Pheromones/metabolism Saccharomyces cerevisiae/cytology/*physiology *S;" |
| Notes: | "MedlineDohlman, Henrik G eng R35 GM118105/GM/NIGMS NIH HHS/ Introductory 2016/02/26 J Biol Chem. 2016 Apr 8; 291(15):7786-7. doi: 10.1074/jbc.R116.722934. Epub 2016 Feb 23" |
