| Title: | The Predictive Role of Biomarkers and Genetics in Childhood Asthma Exacerbations |
| Author(s): | di Palmo E; Cantarelli E; Catelli A; Ricci G; Gallucci M; Miniaci A; Pession A; |
| Address: | "Pediatric Unit-IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy. Specialty School of Paediatrics-Alma Mater Studiorum, Universita di Bologna, 40138 Bologna, Italy. Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy" |
| ISSN/ISBN: | 1422-0067 (Electronic) 1422-0067 (Linking) |
| Abstract: | "Asthma exacerbations are associated with significant childhood morbidity and mortality. Recurrent asthma attacks contribute to progressive loss of lung function and can sometimes be fatal or near-fatal, even in mild asthma. Exacerbation prevention becomes a primary target in the management of all asthmatic patients. Our work reviews current advances on exacerbation predictive factors, focusing on the role of non-invasive biomarkers and genetics in order to identify subjects at higher risk of asthma attacks. Easy-to-perform tests are necessary in children; therefore, interest has increased on samples like exhaled breath condensate, urine and saliva. The variability of biomarker levels suggests the use of seriate measurements and composite markers. Genetic predisposition to childhood asthma onset has been largely investigated. Recent studies highlighted the influence of single nucleotide polymorphisms even on exacerbation susceptibility, through involvement of both intrinsic mechanisms and gene-environment interaction. The role of molecular and genetic aspects in exacerbation prediction supports an individual-shaped approach, in which follow-up planning and therapy optimization take into account not only the severity degree, but also the risk of recurrent exacerbations. Further efforts should be made to improve and validate the application of biomarkers and genomics in clinical settings" |
| Keywords: | Asthma/*etiology/genetics/metabolism Biomarkers/metabolism Child Disease Progression Eosinophilia/immunology/pathology Exhalation Gene-Environment Interaction Genetic Markers Genetic Predisposition to Disease Humans Interleukin-6/blood Nitric Oxide/metabo; |
| Notes: | "Medlinedi Palmo, Emanuela Cantarelli, Erika Catelli, Arianna Ricci, Giampaolo Gallucci, Marcella Miniaci, Angela Pession, Andrea eng Review Switzerland 2021/05/01 Int J Mol Sci. 2021 Apr 28; 22(9):4651. doi: 10.3390/ijms22094651" |
