| Title: | Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children |
| Author(s): | Christian MA; Samms-Vaughan M; Lee M; Bressler J; Hessabi M; Grove ML; Shakespeare-Pellington S; Coore Desai C; Reece JA; Loveland KA; Boerwinkle E; Rahbar MH; |
| Address: | "Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX, USA. Department of Child and Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston, Jamaica. Division of Clinical and Translational Sciences, Department of Internal Medicine, The University of Texas McGovern Medical School, Houston, TX, USA. Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. Department of Psychiatry and Behavioral Sciences, The University of Texas McGovern Medical School, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. Mohammad.H.Rahbar@uth.tmc.edu. Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX, USA. Mohammad.H.Rahbar@uth.tmc.edu. Division of Clinical and Translational Sciences, Department of Internal Medicine, The University of Texas McGovern Medical School, Houston, TX, USA. Mohammad.H.Rahbar@uth.tmc.edu" |
| DOI: | 10.1007/s10803-018-3537-6 |
| ISSN/ISBN: | 1573-3432 (Electronic) 0162-3257 (Print) 0162-3257 (Linking) |
| Abstract: | "Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD" |
| Keywords: | Adult Autism Spectrum Disorder/*epidemiology Child Communicable Diseases/*epidemiology Female Humans Jamaica Male Maternal Exposure/*statistics & numerical data Pesticides/toxicity Pregnancy Volatile Organic Compounds/toxicity Autism spectrum disorder Fev; |
| Notes: | "MedlineChristian, MacKinsey A Samms-Vaughan, Maureen Lee, MinJae Bressler, Jan Hessabi, Manouchehr Grove, Megan L Shakespeare-Pellington, Sydonnie Coore Desai, Charlene Reece, Jody-Ann Loveland, Katherine A Boerwinkle, Eric Rahbar, Mohammad H eng R01 ES022165/ES/NIEHS NIH HHS/ R21HD057808/NH/NIH HHS/ R21 HD057808/HD/NICHD NIH HHS/ UL1 TR003167/TR/NCATS NIH HHS/ R01ES022165/NH/NIH HHS/ UL1 RR024148/RR/NCRR NIH HHS/ UL1 TR000371/TR/NCATS NIH HHS/ 2018/03/20 J Autism Dev Disord. 2018 Aug; 48(8):2766-2778. doi: 10.1007/s10803-018-3537-6" |
