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Integr Zool

Title:		Pheromone 3kPZS evokes context-dependent serotonin sexual dimorphism in the brain of the sea lamprey (Petromyzon marinus)
Author(s):		Chung-Davidson Y; Wang H; Scott AM; Li W;
Address:		"Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, USA"
Journal Title:		Integr Zool
Year:		2015
Volume:		10
Issue:		1
Page Number:		91 - 101
DOI:		10.1111/1749-4877.12099
ISSN/ISBN:		1749-4877 (Electronic) 1749-4869 (Linking)
Abstract:		"Mature male sea lampreys (Petromyzon marinus) release a sex pheromone, 3-keto-petromyzonol sulfate (3kPZS), that induces sexually dimorphic behavioral responses in conspecifics. However, the neural mechanism of such responses is mostly unknown. We examined the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) and the expression of 5-HT1A receptors in the forebrain and brainstem of sea lamprey exposed to the vehicle (0.91 ppm methanol) or 10(-10) M 3kPZS for 2 h using high performance liquid chromatography-electrospray ionization tandem mass spectrometry, immunohistochemistry and real-time quantitative polymerase chain reaction. Exposure to 3kPZS for 2 h increased 5-HT concentration in the forebrain of adult females, whereas 5-HT was not detected in the forebrain of adult males. On the contrary, 3kPZS exposure decreased 5-HT concentration in the brainstem of adult females and had no effect in adult males. Pheromone exposure evoked context-dependent sexual dimorphism in brain 5-HT1A receptor immunoreactivity, but had no effect on 5-HT1A mRNA concentrations in the brain with 2 h exposure time. It appears that in sea lamprey pheromone 3kPZS affects the 5-HT system in the brain in a context-dependent, sexually dimorphic manner"
Keywords:		"Animals Brain/*drug effects/*metabolism Brain Stem/drug effects/metabolism Cholic Acids/*pharmacology Female Gene Expression Regulation Male Petromyzon/*physiology Pheromones/pharmacology Real-Time Polymerase Chain Reaction Receptors, Serotonin, 5-HT1 Ser;"
Notes:		"MedlineChung-Davidson, Yuwen Wang, Huiyong Scott, Anne M Li, Weiming eng 5R24GM83982/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Australia 2014/06/13 Integr Zool. 2015 Jan; 10(1):91-101. doi: 10.1111/1749-4877.12099"