| Title: | The smell of longevity: a combination of Volatile Organic Compounds (VOCs) can discriminate centenarians and their offspring from age-matched subjects and young controls |
| Author(s): | Conte M; Conte G; Martucci M; Monti D; Casarosa L; Serra A; Mele M; Franceschi C; Salvioli S; |
| Address: | "Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy. m.conte@unibo.it. Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, Bologna, Italy. m.conte@unibo.it. Department of Agriculture, Food and Environment, University of Pisa, Pisa, Italy. Research Center of Nutraceuticals and Food for Health, University of Pisa, Pisa, Italy. Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy. Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy. Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia. Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, Bologna, Italy" |
| DOI: | 10.1007/s11357-019-00143-6 |
| ISSN/ISBN: | 2509-2723 (Electronic) 2509-2715 (Print) 2509-2723 (Linking) |
| Abstract: | "Aging is characterized by dynamic changes at metabolic level that lead to modifications in the composition of the metabolome. Since the identification of biomarkers that can discriminate people of different age and health status has recently attracted a great interest, we wondered whether age-specific changes in the metabolome could be identified and serve as new and informative biomarkers of aging and longevity. In the last few years, a specific branch of metabonomics devoted to the study of volatile organic compounds (VOCs) has been developed. To date, little is known about the profile of specific VOCs in healthy aging and longevity in humans; therefore, we investigated the profile of VOCs in both urine and feces samples from 73 volunteers of different age including centenarians that represent useful 'super-controls' to identify potential biomarkers of successful aging and footprints of longevity. To this purpose, we performed a discriminant analysis by which we were able to identify specific profiles of urinary and fecal VOCs. Such profiles can discriminate different age groups, from young to centenarians, and, even more interesting, centenarians' offspring from age-matched controls. Moreover, we were able to identify VOCs that are specific for the couples 'centenarians - offspring' or the trios 'centenarians - offspring - spouse,' suggesting the possible existence of a familiar component also for VOCs profile" |
| Keywords: | "Aged, 80 and over Aging Humans *Longevity Metabolomics Smell *Volatile Organic Compounds Biomarkers Centenarians Human longevity Volatile organic compounds;" |
| Notes: | "MedlineConte, Maria Conte, Giuseppe Martucci, Morena Monti, Daniela Casarosa, Laura Serra, Andrea Mele, Marcello Franceschi, Claudio Salvioli, Stefano eng Research Support, Non-U.S. Gov't Switzerland 2019/12/07 Geroscience. 2020 Feb; 42(1):201-216. doi: 10.1007/s11357-019-00143-6. Epub 2019 Dec 5" |
