« Previous AbstractA truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C    Next AbstractSupplementation of live yeast based feed additive in early life promotes rumen microbial colonization and fibrolytic potential in lambs »

J Investig Med

Title:		Viruses and non-allergen environmental triggers in asthma
Author(s):		Chau-Etchepare F; Hoerger JL; Kuhn BT; Zeki AA; Haczku A; Louie S; Kenyon NJ; Davis CE; Schivo M;
Address:		"Pulmonary, Critical Care, and Sleep Medicine, University of California Davis, Sacramento, California, USA. Internal Medicine, University of California Davis, Sacramento, California, USA. Center for Comparative Respiratory Biology and Medicine, University of California Davis, Davis, California, USA. Mechanical and Aerospace Engineering, University of California Davis, Davis, California, USA"
Journal Title:		J Investig Med
Year:		2019
Volume:		20190727
Issue:		7
Page Number:		1029 - 1041
DOI:		10.1136/jim-2019-001000
ISSN/ISBN:		1708-8267 (Electronic) 1081-5589 (Print) 1081-5589 (Linking)
Abstract:		"Asthma is a complex inflammatory disease with many triggers. The best understood asthma inflammatory pathways involve signals characterized by peripheral eosinophilia and elevated immunoglobulin E levels (called T2-high or allergic asthma), though other asthma phenotypes exist (eg, T2-low or non-allergic asthma, eosinophilic or neutrophilic-predominant). Common triggers that lead to poor asthma control and exacerbations include respiratory viruses, aeroallergens, house dust, molds, and other organic and inorganic substances. Increasingly recognized non-allergen triggers include tobacco smoke, small particulate matter (eg, PM(2.5)), and volatile organic compounds. The interaction between respiratory viruses and non-allergen asthma triggers is not well understood, though it is likely a connection exists which may lead to asthma development and/or exacerbations. In this paper we describe common respiratory viruses and non-allergen triggers associated with asthma. In addition, we aim to show the possible interactions, and potential synergy, between viruses and non-allergen triggers. Finally, we introduce a new clinical approach that collects exhaled breath condensates to identify metabolomics associated with viruses and non-allergen triggers that may promote the early management of asthma symptoms"
Keywords:		Air Pollution/adverse effects Allergens/*immunology Animals Asthma/*immunology/*virology *Environment Humans Smoking/adverse effects Viruses/*immunology asthma tobacco;
Notes:		"MedlineChau-Etchepare, Florence Hoerger, Joshua L Kuhn, Brooks T Zeki, Amir A Haczku, Angela Louie, Samuel Kenyon, Nicholas J Davis, Cristina E Schivo, Michael eng U01 EB022003/EB/NIBIB NIH HHS/ P30 ES023513/ES/NIEHS NIH HHS/ UL1 TR000002/TR/NCATS NIH HHS/ TL1 TR001861/TR/NCATS NIH HHS/ UH3 OD023365/OD/NIH HHS/ UG3 OD023365/OD/NIH HHS/ K23 HL127185/HL/NHLBI NIH HHS/ Research Support, N.I.H., Extramural Review England 2019/07/29 J Investig Med. 2019 Oct; 67(7):1029-1041. doi: 10.1136/jim-2019-001000. Epub 2019 Jul 27"