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Nat Commun

Title:		Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system
Author(s):		Chai PC; Cruchet S; Wigger L; Benton R;
Address:		"Center for Integrative Genomics, Genopode Building, Faculty of Biology and Medicine, University of Lausanne, 1015, Lausanne, Switzerland. Lausanne Genomic Technologies Facility, Genopode Building, Faculty of Biology and Medicine, University of Lausanne, 1015, Lausanne, Switzerland. Vital-IT Group, SIB Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland. Center for Integrative Genomics, Genopode Building, Faculty of Biology and Medicine, University of Lausanne, 1015, Lausanne, Switzerland. Richard.Benton@unil.ch"
Journal Title:		Nat Commun
Year:		2019
Volume:		20190207
Issue:		1
Page Number:		643 -
DOI:		10.1038/s41467-019-08345-4
ISSN/ISBN:		2041-1723 (Electronic) 2041-1723 (Linking)
Abstract:		"Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe specific lineages, especially at early developmental stages prior to expression of unique molecular markers. Here, we use a genetic immortalization method to analyze the development of sensory neuron lineages in the Drosophila olfactory system, from their origin to terminal differentiation. We apply this approach to define a fate map of nearly all olfactory lineages and refine the model of temporal patterns of lineage divisions. Taking advantage of a selective marker for the lineage that gives rise to Or67d pheromone-sensing neurons and a genome-wide transcription factor RNAi screen, we identify the spatial and temporal requirements for Pointed, an ETS family member, in this developmental pathway. Transcriptomic analysis of wild-type and Pointed-depleted olfactory tissue reveals a universal requirement for this factor as a switch-like determinant of fates in these sensory lineages"
Keywords:		Animals Drosophila Drosophila Proteins/metabolism Olfactory Bulb/*cytology/*metabolism Sensory Receptor Cells/*cytology/*metabolism;
Notes:		"MedlineChai, Phing Chian Cruchet, Steeve Wigger, Leonore Benton, Richard eng 615094/ERC_/European Research Council/International P40 OD018537/OD/NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2019/02/09 Nat Commun. 2019 Feb 7; 10(1):643. doi: 10.1038/s41467-019-08345-4"