| Title: | Target-Specific Capture of Environmentally Relevant Gaseous Aldehydes and Carboxylic Acids with Functional Nanoparticles |
| Author(s): | Campbell ML; Guerra FD; Dhulekar J; Alexis F; Whitehead DC; |
| Address: | "Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC 29634 (USA). Department of Bioengineering, Clemson University, 203 Rhodes Annex, Clemson, SC 29634 (USA), Fax: (+1) 864-656-4466. CAPES Foundation, Ministry of Education of Brazil, Brasilia - DF 70040-020 (Brazil). Department of Bioengineering, Clemson University, 203 Rhodes Annex, Clemson, SC 29634 (USA), Fax: (+1) 864-656-4466. falexis@clemson.edu. Institute of Biological Interfaces of Engineering, Department of Bioengineering, Clemson University, 401-2 Rhodes Engineering Research Center, Clemson, SC 29634 (USA). falexis@clemson.edu. Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC 29634 (USA). dwhiteh@clemson.edu" |
| ISSN/ISBN: | 1521-3765 (Electronic) 0947-6539 (Linking) |
| Abstract: | "Aldehyde and carboxylic acid volatile organic compounds (VOCs) present significant environmental concern due to their prevalence in the atmosphere. We developed biodegradable functional nanoparticles comprised of poly(d,l-lactic acid)-poly(ethylene glycol)-poly(ethyleneimine) (PDLLA-PEG-PEI) block co-polymers that capture these VOCs by chemical reaction. Polymeric nanoparticles (NPs) preparation involved nanoprecipitation and surface functionalization with branched PEI. The PDLLA-PEG-PEI NPs were characterized by using TGA, IR, (1) H NMR, elemental analysis, and TEM. The materials feature 1 degrees , 2 degrees , and 3 degrees amines on their surface, capable of capturing aldehydes and carboxylic acids from gaseous mixtures. Aldehydes were captured by a condensation reaction forming imines, whereas carboxylic acids were captured by acid/base reaction. These materials reacted selectively with target contaminants obviating off-target binding when challenged by other VOCs with orthogonal reactivity. The NPs outperformed conventional activated carbon sorbents" |
| Keywords: | Aldehydes/*chemistry Biocompatible Materials/*chemistry Carbon/*chemistry Carboxylic Acids/*chemistry Environmental Exposure Environmental Pollutants/*chemistry Lactic Acid/*chemistry Nanoparticles/*chemistry Polyesters Polyethyleneimine/*chemistry Polyme; |
| Notes: | "MedlineCampbell, McKenzie L Guerra, Fernanda D Dhulekar, Jhilmil Alexis, Frank Whitehead, Daniel C eng 5P20M103444-07/PHS HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Germany 2015/09/04 Chemistry. 2015 Oct 12; 21(42):14834-42. doi: 10.1002/chem.201502021. Epub 2015 Sep 1" |
