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Chin J Integr Med

Title:		Qualitative analysis of a sulfur-fumigated Chinese herbal medicine by comprehensive two-dimensional gas chromatography and high-resolution time of flight mass spectrometry using colorized fuzzy difference data processing
Author(s):		Cai H; Cao G; Zhang HY;
Address:		"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. caogang33@163.com. Research Center of Traditional Chinese Medicine Processing Technology, Zhejiang Chinese Medical University, Hangzhou, 310053, China. caogang33@163.com. Zhejiang Cancer Hospital, Hangzhou, 310022, China"
Journal Title:		Chin J Integr Med
Year:		2017
Volume:		20150324
Issue:		4
Page Number:		261 - 269
DOI:		10.1007/s11655-015-1966-z
ISSN/ISBN:		1672-0415 (Print) 1672-0415 (Linking)
Abstract:		OBJECTIVE: To investigate the chemical transformation of volatile compounds in sulfur-fumigated Radix Angelicae Sinensis. METHODS: A comprehensive two-dimensional gas chromatography (GCxGC) and high-resolution time-of-flight mass spectrometry (HR-TOF/MS) with colorized fuzzy difference (CFD) method was used to investigate the effect of sulfur-fumigation on the volatile components from Radix Angelicae Sinensis. RESULTS: Twenty-five compounds that were found in sun-dried samples disappeared in sulfur-fumigated samples. Seventeen volatile components including two sulfur-containing compounds were newly generated for the first time in volatile oils of sulfur-fumigated Radix Angelicae Sinensis. CONCLUSION: The strategy can be successfully applied to rapidly and holistically discriminate sun-dried and sulfur-fumigated Radix Angelicae Sinensis. GCxGC-HR-TOF/MS based CFD is a powerful and feasible approach for the global quality evaluation of Radix Angelicae Sinensis as well as other herbal medicines
Keywords:		"Angelica sinensis Color Drugs, Chinese Herbal/*analysis *Fumigation *Fuzzy Logic Gas Chromatography-Mass Spectrometry/*methods Oils, Volatile/analysis Reference Standards Sulfur/*analysis Volatile Organic Compounds/analysis Radix Angelicae Sinensis colori;"
Notes:		"MedlineCai, Hao Cao, Gang Zhang, Hong-Yan eng China 2015/03/26 Chin J Integr Med. 2017 Apr; 23(4):261-269. doi: 10.1007/s11655-015-1966-z. Epub 2015 Mar 24"