« Previous AbstractTarget the neglected VOCs emission from iron and steel industry in China for air quality improvement    Next AbstractProfiling and characterization of volatile components from non-fumigated and sulfur-fumigated Flos Lonicerae Japonicae using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry coupled with chemical group separation »

R Soc Open Sci

Title:		Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core-shell nanocarriers
Author(s):		Cai D; Fan J; Wang S; Long R; Zhou X; Liu Y;
Address:		"College of Chemical Engineering, Huaqiao University, Xiamen 361021, People's Republic of China. Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, People's Republic of China. Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 361021, People's Republic of China"
Journal Title:		R Soc Open Sci
Year:		2018
Volume:		20180718
Issue:		7
Page Number:		180320 -
DOI:		10.1098/rsos.180320
ISSN/ISBN:		2054-5703 (Print) 2054-5703 (Electronic) 2054-5703 (Linking)
Abstract:		"Layer-by-layer (LbL) self-assembly is the technology used in intermolecular static electricity, hydrogen bonds, covalent bonds and other polymer interactions during film assembling. This technology has been widely studied in the drug carrier field. Given their use in drug delivery systems, the biocompatibility of these potential compounds should be addressed. In this work, the primary biocompatibility of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) [PLGA-(PLO/fucoidan)] core-shell nanoparticles (NPs) was investigated. Atomic force microscopy revealed the PLGA-(PLO/Fucoidan)(4) NPs to be spherical, with a uniform size distribution and a smooth surface, and the NPs were stable in physiological saline. The residual amount of methylene chloride was further determined by headspace gas chromatography, in which the organic solvent can be volatilized during preparation. Furthermore, cell viability, acridine orange/ethidium bromide staining, haemolysis and mouse systemic toxicity were all assessed to show that PLGA-(PLO/fucoidan)(4) NPs were biocompatible with cells and mice. Therefore, these NPs are expected to have potential applications in future drug delivery systems"
Keywords:		Plga anti-tumour biocompatibility fucoidan layer-by-layer self-assembly poly-ornithine;
Notes:		"PubMed-not-MEDLINECai, Duanhua Fan, Jingqian Wang, Shibin Long, Ruimin Zhou, Xia Liu, Yuangang eng England 2018/08/16 R Soc Open Sci. 2018 Jul 18; 5(7):180320. doi: 10.1098/rsos.180320. eCollection 2018 Jul"