| Title: | The olfactory subgenome and specific odor recognition in forest musk deer |
| Author(s): | Bu P; Jian Z; Koshy J; Shen Y; Yue B; Fan Z; |
| Address: | "Key Laboratory of Bioresources and Ecoenvironment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, 610064, China. Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Sciences, Sichuan University, Chengdu, 610064, China. Sichuan Engineering Research Center for Medicinal Animals, Xichang, 615000, China" |
| ISSN/ISBN: | 1365-2052 (Electronic) 0268-9146 (Linking) |
| Abstract: | "Olfactory receptors (ORs) are encoded by OR genes. The OR genes in forest musk deer (Moschus berezovskii), which rely on olfaction for reproductive and social communication, are poorly understood. In this study, we analyzed the genome sequence of the forest musk deer to obtain its olfactory subgenome and compared it to other species. A total of 1378 OR-related sequences were detected in the forest musk deer genome including 864 functional genes, 366 pseudogenes and 148 partial genes. These OR genes were classified into Class I and Class II and were further classified into 18 families and 244 subfamilies through sequence identity. Comparative analyses of the OR genes' protein sequences in species from different orders (forest musk deer, human, mouse and dog) showed that 12 clusters were specific to forest musk deer. However, when compared to other Artiodactyl species (i.e. cattle, yak and pig) only two clusters were specific to forest musk deer. The odor identification potential of the OR genes in the forest musk deer was focused mainly on floral, woody, lemon, sweet and fatty odors. We also found that OR genes specific to forest musk deer were involved in the identification of spearmint and caraway. Our work is the first genome-wide analysis of OR genes in forest musk deer. These findings will assist with better understanding the relationship between behavior and olfaction in the forest musk deer and the characteristics of the olfactory subgenome in Artiodactyl mammals" |
| Keywords: | "Animals Deer/*genetics Humans Male Odorants Phylogeny Receptors, Odorant/*genetics forest musk deer genome-wide analysis odor recognition olfactory receptor;" |
| Notes: | "MedlineBu, P Jian, Z Koshy, J Shen, Y Yue, B Fan, Z eng 2016YFC0503200/National Key Program of Research and Development, Ministry of Science and Technology/ England 2019/05/21 Anim Genet. 2019 Aug; 50(4):358-366. doi: 10.1111/age.12796. Epub 2019 May 20" |
