« Previous AbstractOptimization of the production of a honeybee odorant-binding protein by Pichia pastoris    Next AbstractRobotic mechanical wounding (MecWorm) versus herbivore-induced responses: early signaling and volatile emission in Lima bean (Phaseolus lunatus L.) »

mBio

Title:		Volatile Compounds Emitted by Pseudomonas aeruginosa Stimulate Growth of the Fungal Pathogen Aspergillus fumigatus
Author(s):		Briard B; Heddergott C; Latge JP;
Address:		"Aspergillus Unit, Pasteur Institute, Paris, France. Aspergillus Unit, Pasteur Institute, Paris, France jean-paul.latge@pasteur.fr"
Journal Title:		mBio
Year:		2016
Volume:		20160315
Issue:		2
Page Number:		e00219 -
DOI:		10.1128/mBio.00219-16
ISSN/ISBN:		2150-7511 (Electronic)
Abstract:		"Chronic lung infections with opportunistic bacterial and fungal pathogens are a major cause of morbidity and mortality especially in patients with cystic fibrosis. Pseudomonas aeruginosa is the most frequently colonizing bacterium in these patients, and it is often found in association with the filamentous fungus Aspergillus fumigatus. P. aeruginosa is known to inhibit the growth of A. fumigatus in situations of direct contact, suggesting the existence of interspecies communication that may influence disease outcome. Our study shows that the lung pathogens P. aeruginosa and A. fumigatus can interact at a distance via volatile-mediated communication and expands our understanding of interspecific signaling in microbial communities. IMPORTANCE: Microbiota studies have shown that pathogens cannot be studied individually anymore and that the establishment and progression of a specific disease are due not to a single microbial species but are the result of the activity of many species living together. To date, the interaction between members of the human microbiota has been analyzed in situations of direct contact or liquid-mediated contact between organisms. This study showed unexpectedly that human opportunistic pathogens can interact at a distance after sensing volatiles emitted by another microbial species. This finding will open a new research avenue for the understanding of microbial communities"
Keywords:		Aspergillus fumigatus/*drug effects/*growth & development Growth Substances/*metabolism/pharmacology *Microbial Interactions Pseudomonas aeruginosa/*metabolism Volatile Organic Compounds/*metabolism/pharmacology;
Notes:		"MedlineBriard, Benoit Heddergott, Christoph Latge, Jean-Paul eng Research Support, Non-U.S. Gov't 2016/03/17 mBio. 2016 Mar 15; 7(2):e00219. doi: 10.1128/mBio.00219-16"