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Learn Mem

Title:		Social modulation of associative fear learning by pheromone communication
Author(s):		Bredy TW; Barad M;
Address:		"Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California 90095, USA. tbredy@mednet.ucla.edu"
Journal Title:		Learn Mem
Year:		2009
Volume:		20081230
Issue:		1
Page Number:		12 - 18
DOI:		10.1101/lm.1226009
ISSN/ISBN:		1549-5485 (Electronic) 1072-0502 (Print) 1072-0502 (Linking)
Abstract:		"Mice communicate through visual, vocal, and olfactory cues that influence innate, nonassociative behavior. We here report that exposure to a recently fear-conditioned familiar mouse impairs acquisition of conditioned fear and facilitates fear extinction, effects mimicked by both an olfactory chemosignal emitted by a recently fear-conditioned familiar mouse and by the putative stress-related anxiogenic pheromone beta-phenylethylamine (beta-PEA). Together, these findings suggest social modulation of higher-order cognitive processing through pheromone communication and support the concurrent excitor hypothesis of extinction learning"
Keywords:		"Animals Association Learning/*physiology Behavior, Animal/*physiology Extinction, Psychological/physiology Fear/*physiology Mice Motor Activity/drug effects Pain Threshold/drug effects Phenethylamines/pharmacology Pheromones/*physiology Psychotropic Drugs;Neuroscience;"
Notes:		"MedlineBredy, Timothy W Barad, Mark eng Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2009/01/02 Learn Mem. 2008 Dec 30; 16(1):12-8. doi: 10.1101/lm.1226009. Print 2009 Jan"