« Previous Abstract"Predator-mediated plasticity in morphology, life history, and behavior of Daphnia: the uncoupling of responses"    Next AbstractRemote blubber sampling paired with liquid chromatography tandem mass spectrometry for steroidal endocrinology in free-ranging bottlenose dolphins (Tursiops truncatus) »

Regul Toxicol Pharmacol

Title:		Pharmacokinetics for regulatory risk analysis: the case of trichloroethylene
Author(s):		Bogen KT;
Address:		"Environmental Sciences Division, Lawrence Livermore National Laboratory, Livermore, California 94550"
Journal Title:		Regul Toxicol Pharmacol
Year:		1988
Volume:		8
Issue:		4
Page Number:		447 - 466
DOI:		10.1016/0273-2300(88)90045-1
ISSN/ISBN:		0273-2300 (Print) 0273-2300 (Linking)
Abstract:		"Physiologically based pharmacokinetic (PBPK) models describing the uptake, metabolism, and excretion of volatile organic compounds (VOCs) are now proposed for use in regulatory health-risk assessment. A steady-state analysis of one such model is shown to provide simple, convenient predicted relationships between an applied dose and the corresponding toxicologically effective, metabolized dose for certain VOCs like trichloroethylene (TCE). A version of this PBPK model was fit to data on human metabolism of TCE to urinary metabolites in chronically exposed workers, yielding a direct estimate of PBPK parameters governing human capacity to metabolize TCE. It is shown that this estimate is consistent with others based on experimental studies of TCE metabolism in humans exposed to TCE by inhalation for short periods. These results are applied to human cancer-risk assessment using rodent bioassay data on TCE-induced tumorigenesis"
Keywords:		Carcinogenicity Tests Humans Risk Factors Trichloroethylene/*pharmacokinetics/toxicity;
Notes:		"MedlineBogen, K T eng Research Support, U.S. Gov't, Non-P.H.S. Netherlands 1988/12/01 Regul Toxicol Pharmacol. 1988 Dec; 8(4):447-66. doi: 10.1016/0273-2300(88)90045-1"