| Title: | Quantification of 31 volatile organic compounds in whole blood using solid-phase microextraction and gas chromatography-mass spectrometry |
| Author(s): | Blount BC; Kobelski RJ; McElprang DO; Ashley DL; Morrow JC; Chambers DM; Cardinali FL; |
| Address: | "Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. BBlount@cdc.gov" |
| Journal Title: | J Chromatogr B Analyt Technol Biomed Life Sci |
| DOI: | 10.1016/j.jchromb.2006.01.019 |
| ISSN/ISBN: | 1570-0232 (Print) 1570-0232 (Linking) |
| Abstract: | "The prevalence of exposure to volatile organic compounds (VOCs) has raised concern about possible health effects resulting from chronic human exposure. To support studies exploring the relation between VOC exposure and health effects, we developed an automated analytical method using solid-phase microextraction (SPME), capillary gas chromatography (GC), and quadrupole mass spectrometry (MS). This method quantifies trace levels (low parts per trillion) of 14 halogenated alkanes, 5 halogenated alkenes, 10 aromatic compounds, and 2 other VOCs in human blood. Detection limits for the SPME-GC-MS method range from 0.005 to 0.12 microg/L, with linear calibration curves spanning three orders of magnitude. The improved throughput of this method will enable us to expand biomonitoring efforts to assess nonoccupational VOC exposure in large epidemiological studies" |
| Keywords: | Gas Chromatography-Mass Spectrometry/*methods Humans Organic Chemicals/*blood Quality Control Reference Standards Volatilization; |
| Notes: | "MedlineBlount, Benjamin C Kobelski, Robert J McElprang, David O Ashley, David L Morrow, John C Chambers, David M Cardinali, Frederick L eng Netherlands 2006/02/24 J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Mar 7; 832(2):292-301. doi: 10.1016/j.jchromb.2006.01.019. Epub 2006 Feb 21" |
