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Elife

Title:		Sex-specific processing of social cues in the medial amygdala
Author(s):		Bergan JF; Ben-Shaul Y; Dulac C;
Address:		"Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, United States. School of Medicine, Department of Medical Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel. Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, United States dulac@fas.harvard.edu"
Journal Title:		Elife
Year:		2014
Volume:		20140603
Issue:
Page Number:		e02743 -
DOI:		10.7554/eLife.02743
ISSN/ISBN:		2050-084X (Electronic) 2050-084X (Linking)
Abstract:		"Animal-animal recognition within, and across species, is essential for predator avoidance and social interactions. Despite its essential role in orchestrating responses to animal cues, basic principles of information processing by the vomeronasal system are still unknown. The medial amygdala (MeA) occupies a central position in the vomeronasal pathway, upstream of hypothalamic centers dedicated to defensive and social responses. We have characterized sensory responses in the mouse MeA and uncovered emergent properties that shed new light onto the transformation of vomeronasal information into sex- and species-specific responses. In particular, we show that the MeA displays a degree of stimulus selectivity and a striking sexually dimorphic sensory representation that are not observed in the upstream relay of the accessory olfactory bulb (AOB). Furthermore, our results demonstrate that the development of sexually dimorphic circuits in the MeA requires steroid signaling near the time of puberty to organize the functional representation of sensory stimuli.DOI: http://dx.doi.org/10.7554/eLife.02743.001"
Keywords:		"Amygdala/*physiology Animals Cues Female Hormones/metabolism Male Mice Mice, Inbred BALB C Neurons/metabolism Odorants Olfactory Bulb/physiology Olfactory Mucosa/physiology *Sex Factors Sexual Behavior, Animal/physiology Vomeronasal Organ/physiology behav;"
Notes:		"MedlineBergan, Joseph F Ben-Shaul, Yoram Dulac, Catherine eng R01DC013087/DC/NIDCD NIH HHS/ R01DC009019/DC/NIDCD NIH HHS/ F32 DC10089/DC/NIDCD NIH HHS/ R01 DC013087/DC/NIDCD NIH HHS/ F32 DC010089/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2014/06/05 Elife. 2014 Jun 3; 3:e02743. doi: 10.7554/eLife.02743"