| Title: | Sex-steroid derived compounds induce sex-specific effects on autonomic nervous system function in humans |
| Author(s): | Bensafi M; Brown WM; Tsutsui T; Mainland JD; Johnson BN; Bremner EA; Young N; Mauss I; Ray B; Gross J; Richards J; Stappen I; Levenson RW; Sobel N; |
| Address: | "Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley 94720, USA. bensafi@uclink.berkeley.edu" |
| DOI: | 10.1037/0735-7044.117.6.1125 |
| ISSN/ISBN: | 0735-7044 (Print) 0735-7044 (Linking) |
| Abstract: | "The physiological and psychological effects of 2 human sex-steroid derived compounds, 4.16-androstadien-3-one (AND) and l,3,5(10),16-estratetraen-3-ol(EST) were measured in 24 subjects who participated in a within-subjects, double-blind experiment. A dissociation was evident in the physiological effects of AND, in that it increased physiological arousal in women but decreased it in men. EST did not significantly affect physiological arousal in women or men. Neither compound significantly affected mood. AND is an androgen derivative that is the most prevalent androstene in human male sweat, male axillary hair, and on the male axillary skin surface. The authors argue that AND's opposite effects on physiology in men and women further implicate this compound in chemical communication between humans" |
| Keywords: | Adult Affect/drug effects Analysis of Variance Androstadienes/*pharmacology Arousal/*drug effects Autonomic Nervous System/*drug effects Double-Blind Method Estrenes/*pharmacology Female Humans Male Odorants Sex Attractants/*pharmacology Sex Factors;Neuroscience; |
| Notes: | "MedlineBensafi, M Brown, W M Tsutsui, T Mainland, J D Johnson, B N Bremner, E A Young, N Mauss, I Ray, B Gross, J Richards, J Stappen, I Levenson, R W Sobel, N eng Clinical Trial Comparative Study Controlled Clinical Trial Research Support, Non-U.S. Gov't 2003/12/17 Behav Neurosci. 2003 Dec; 117(6):1125-34. doi: 10.1037/0735-7044.117.6.1125" |
