| Title: | The potential of volatile organic compound analysis for pathogen detection and disease monitoring in patients with cystic fibrosis |
| Author(s): | Barucha A; Mauch RM; Duckstein F; Zagoya C; Mainz JG; |
| Address: | "Cystic Fibrosis Center for Children and Adults, Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg, Brandenburg an der Havel, Germany. Center for Investigation in Pediatrics, School of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil. Faculty of Health Sciences, joint Faculty of the Brandenburg University of Technology Cottbus-Senftenberg, The Brandenburg Medical School Theodor Fontane and the University of Potsdam, Germany" |
| DOI: | 10.1080/17476348.2022.2104249 |
| ISSN/ISBN: | 1747-6356 (Electronic) 1747-6348 (Linking) |
| Abstract: | "INTRODUCTION: Airway infection with pathogens and its associated pulmonary exacerbations (PEX) are the major causes of morbidity and premature death in cystic fibrosis (CF). Preventing or postponing chronic infections requires early diagnosis. However, limitations of conventional microbiology-based methods can hamper identification of exacerbations and specific pathogen detection. Analyzing volatile organic compounds (VOCs) in breath samples may be an interesting tool in this regard, as VOC-biomarkers can characterize specific airway infections in CF. AREAS COVERED: We address the current achievements in VOC-analysis and discuss studies assessing VOC-biomarkers and fingerprints, i.e. a combination of multiple VOCs, in breath samples aiming at pathogen and PEX detection in people with CF (pwCF). We aim to provide bases for further research in this interesting field. EXPERT OPINION: Overall, VOC-based analysis is a promising tool for diagnosis of infection and inflammation with potential to monitor disease progression in pwCF. Advantages over conventional diagnostic methods, including easy and non-invasive sampling procedures, may help to drive prompt, suitable therapeutic approaches in the future. Our review shall encourage further research, including validation of VOC-based methods. Specifically, longitudinal validation under standardized conditions is of interest in order to ensure repeatability and enable inclusion in CF diagnostic routine" |
| Keywords: | Biomarkers Breath Tests *Cystic Fibrosis Humans *Volatile Organic Compounds Breath analysis Pseudomonas aeruginosa cystic fibrosis pathogens volatile organic compounds; |
| Notes: | "MedlineBarucha, Anton Mauch, Renan M Duckstein, Franziska Zagoya, Carlos Mainz, Jochen G eng Review England 2022/07/20 Expert Rev Respir Med. 2022 Jul; 16(7):723-735. doi: 10.1080/17476348.2022.2104249. Epub 2022 Aug 1" |
