| Title: | Volatile organic compound detection as a potential means of diagnosing cutaneous wound infections |
| Author(s): | Ashrafi M; Bates M; Baguneid M; Alonso-Rasgado T; Rautemaa-Richardson R; Bayat A; |
| Address: | "Plastic and Reconstructive Surgery Research, Institute of Inflammation and Repair, Centre for Dermatological Research, University of Manchester, Manchester, United Kingdom. University Hospital South Manchester NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom. Bioengineering Group, School of Materials, University of Manchester, Manchester, United Kingdom. MCBA Consulting, Cardiff, United Kingdom. Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom" |
| ISSN/ISBN: | 1524-475X (Electronic) 1067-1927 (Linking) |
| Abstract: | "Chronic cutaneous wound infections and surgical site infections (SSIs) present a huge burden on the healthcare system and can lead to increased morbidity and mortality. Current diagnostic methods of identifying and confirming infection involve culture-based and molecular methods. Both techniques are time-consuming and delays commonly lead to untargeted empirical treatment. An ideal diagnostic method would be noninvasive and highly sensitive and detect pathogenic organisms with a high degree of accuracy to allow targeted treatment. Volatile organic compounds (VOCs) are a diverse group of carbon-based molecules produced and released by humans and microorganisms. VOC detection has the potential in aiding cutaneous wound infection diagnostics using noninvasive and time-efficient methods. This review provides a comprehensive update on VOCs produced and emitted by bacteria commonly associated with chronic wounds and SSIs. VOC sampling has the advantage of being painless, time-efficient, noninvasive, and reproducible. VOCs emitted by these organisms are diverse. In vitro studies have identified potential signature volatile profiles, which can be used in detecting these microorganisms. Combining these profiles with volatile profiles emitted from acute, chronic and surgical wounds in vivo could potentially allow identification of bacterial-specific VOCs. VOC detection has the potential for a relatively inexpensive, portable, noninvasive, and reliable clinical diagnostic tool, which could be used in detecting cutaneous wound infections and guiding their optimal management" |
| Keywords: | Bacterial Infections/*diagnosis/metabolism Gas Chromatography-Mass Spectrometry Humans Sensitivity and Specificity Volatile Organic Compounds/*analysis Wound Healing Wound Infection/*diagnosis/metabolism Wounds and Injuries/metabolism/*microbiology; |
| Notes: | "MedlineAshrafi, Mohammed Bates, Matt Baguneid, Mohamed Alonso-Rasgado, Teresa Rautemaa-Richardson, Riina Bayat, Ardeshir eng Review 2017/07/21 Wound Repair Regen. 2017 Aug; 25(4):574-590. doi: 10.1111/wrr.12563. Epub 2017 Aug 31" |
