| Title: | Volatile compounds of Lamiaceae exhibit a synergistic antibacterial activity with streptomycin |
| Author(s): | Araujo SG; Alves LF; Pinto ME; Oliveira GT; Siqueira EP; Ribeiro RI; Ferreira JM; Lima LA; |
| Address: | "Universidade Federal de Sao Joao del-Rei Campus Centro-Oeste Dona Lindu, DivinopolisMG Brazil Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis, MG, Brazil. Laboratorio de Quimica de Produtos Naturais Centro de Pesquisas Rene Rachou Fiocruz, Belo HorizonteMG Brazil Laboratorio de Quimica de Produtos Naturais, Centro de Pesquisas Rene Rachou, Fiocruz, Belo Horizonte, MG, Brazil" |
| DOI: | 10.1590/s1517-83822014000400026 |
| ISSN/ISBN: | 1678-4405 (Electronic) 1517-8382 (Print) 1517-8382 (Linking) |
| Abstract: | "Bacterial infections cause thousands of deaths in the world every year. In most cases, infections are more serious because the patient is already weakened, and often, the bacteria are already resistant to the antibiotics used. Counterparting this negative scenario, the interest in medicinal plants as an alternative to the synthetic antimicrobial drugs is blossoming worldwide. In the present work, we identified the volatile compounds of ethanol extracts of Melissa officinalis, Mentha sp., Ocimum basilicum, Plectranthus barbatus, and Rosmarinus officinalis by gas chromatography/mass spectrometry (GC/MS). Also was evaluated antimicrobial activity of ethanol extracts against 6 bacteria of clinical interest, and was tested the interaction of these extracts with a commercial antibiotic streptomycin. Phytol was a compound identified in all extracts by GC/MS, being majoritary component in Plectranthus barbatus and Rosmarinus officinalis. The Gram-positive bacteria were more sensitive to ethanol extracts, and Plectranthus barbatus and Rosmarinus officinalis were the most active extracts. Ethanol extracts exhibited a synergetic effect with streptomycin. These results encourage additional studies, in order to evaluate the possibilities of using ethanol extracts of Lamiaceae family as natural source for antibacterial activity" |
| Keywords: | Anti-Bacterial Agents/isolation & purification/*pharmacology Bacteria/*drug effects *Drug Synergism Gas Chromatography-Mass Spectrometry Humans Lamiaceae/*chemistry Microbial Sensitivity Tests Plant Extracts/isolation & purification/*pharmacology Streptom; |
| Notes: | "MedlineAraujo, Sthefane G Alves, Lucas F Pinto, Maria Eduarda A Oliveira, Graziela T Siqueira, Ezequias P Ribeiro, Rosy I M A Ferreira, Jaqueline M S Lima, Luciana A R S eng Research Support, Non-U.S. Gov't Brazil 2014/01/01 Braz J Microbiol. 2015 Mar 4; 45(4):1341-7. doi: 10.1590/s1517-83822014000400026. eCollection 2014" |
