| Title: | The potential of breath analysis to improve outcome for patients with lung cancer |
| Author(s): | Antoniou SX; Gaude E; Ruparel M; van der Schee MP; Janes SM; Rintoul RC; The Lu CIDG; |
| Address: | "Lungs for Living Research Centre, UCL Respiratory, University College London, London, United Kingdom. Equal contribution. Owlstone Medical, Cambridge, United Kingdom Papworth Trials Unit Collaboration, Royal Papworth Hospital, Cambridge, United Kingdom Department of Oncology, University of Cambridge, United Kingdom" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "Lung cancer remains the most common cause of cancer related death in both the UK and USA. Development of diagnostic approaches that have the ability to detect lung cancer early are a research priority with potential to improve survival. Analysis of exhaled breath metabolites, or volatile organic compounds (VOCs) is an area of considerable interest as it could fulfil such requirements. Numerous studies have shown that VOC profiles are different in the breath of patients with lung cancer compared to healthy individuals or those with non-malignant lung diseases. This review provides a scientific and clinical assessment of the potential value of a breath test in lung cancer. It discusses the current understanding of metabolic pathways that contribute to exhaled VOC production in lung cancer and reviews the research conducted to date. Finally, we highlight important areas for future research and discuss how a breath test could be incorporated into various clinical pathways" |
| Keywords: | Breath Tests/*methods Humans Lung Neoplasms/*diagnosis Treatment Outcome; |
| Notes: | "MedlineAntoniou, S X Gaude, E Ruparel, M van der Schee, M P Janes, S M Rintoul, R C eng WT_/Wellcome Trust/United Kingdom DH_/Department of Health/United Kingdom Research Support, Non-U.S. Gov't England 2019/03/02 J Breath Res. 2019 Apr 24; 13(3):034002. doi: 10.1088/1752-7163/ab0bee" |
