| Title: | "Synthesis, Bioassays and Field Evaluation of Hydroxycoumarins and their Alkyl Derivatives as Repellents or Kairomones for Aedes albopictus Skuse (Diptera: Culicidae)" |
| Author(s): | Andrianjafy TM; Ravaomanarivo LH; Ramanandraibe VV; Rakotondramanga MF; Mavingui P; Lemaire M; |
| Address: | "Laboratory International Associates, University of Antananarivo-University of Lyon 1, PO Box 906, Antananarivo, Madagascar. Department of Entomology, University of Antananarivo, PO Box 906, Antananarivo, Madagascar. Universite de La Reunion, UMR PIMIT, INSERM 1187, CNRS 9192, IRD 249. Plateforme CYROI, 2 Rue Maxime Riviere, Sainte Clotilde, La Reunion, France. Laboratory International Associates, University of Antananarivo-University of Lyon 1, PO Box 906, Antananarivo, Madagascar. marc.lemaire.chimie@univ-lyon1.fr. ICBMS, CNRS, UMR 5246, University of Claude Bernard Lyon 1, 43 Bd du 11 Novembre 1918. Bat CPE, 69622, Villeurbanne, France. marc.lemaire.chimie@univ-lyon1.fr" |
| DOI: | 10.1007/s10886-018-0931-7 |
| ISSN/ISBN: | 1573-1561 (Electronic) 0098-0331 (Linking) |
| Abstract: | "In recent years, a significant increase in mosquito-borne diseases has been recorded worldwide. Faced with the limitations of existing methods for controlling the vector mosquito population, the development of attractants to bait traps and repellents to limit host-vector contacts could be promising and environmentally-friendly control strategies. The purpose of this study was to evaluate the effect of hydroxycoumarins and their alkyls derivatives against Aedes albopictus, the main vector of several arboviruses. Synthesis, bioassays and field trials were carried out in Madagascar. The results showed that 3, 4 and 6-hydroxycoumarins are attractive to this mosquito, 4-hydroxycoumarin being the most effective both in the laboratory and under field conditions. In addition, a good synergistic effect was found with octenol to attract mosquitoes and especially Ae. albopictus in comparison to other mosquito species living in sympatry. On the contrary, the 4-s-butoxycoumarin and 4-s-pentoxycoumarin derivatives had a repellent effect with the former showing the most significant effect. Further optimization of the dose and structure of these products will be carried out in order to maximize their utility for the control of Ae. albopictus and other mosquitoes" |
| Keywords: | "Aedes/*drug effects Alkylation Animals Behavior, Animal/drug effects *Biological Assay Chemistry Techniques, Synthetic Coumarins/*chemical synthesis/chemistry/*pharmacology Insect Repellents/chemical synthesis/chemistry/pharmacology Pheromones/chemical sy;" |
| Notes: | "MedlineAndrianjafy, Tovo Mbolatiana Ravaomanarivo, Lala Harivelo Ramanandraibe, Voahangy Vestalys Rakotondramanga, Maonja Finaritra Mavingui, Patrick Lemaire, Marc eng 2018/03/11 J Chem Ecol. 2018 Mar; 44(3):299-311. doi: 10.1007/s10886-018-0931-7. Epub 2018 Mar 10" |
