| Title: | Role of neuropeptides in sex pheromone production in moths |
| Address: | "Department of Entomology, The Volcani Center, Bet Dagan, 50250 Israel. vinnie2@agri.gov.il" |
| DOI: | 10.1016/j.peptides.2004.06.020 |
| ISSN/ISBN: | 0196-9781 (Print) 0196-9781 (Linking) |
| Abstract: | "Sex pheromone biosynthesis in many moth species is controlled by a cerebral neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a 33 amino acid C-terminally amidated neuropeptide that is produced by neuroendocrine cells of the subesophageal ganglion (SEG). Studies of the regulation of sex pheromone biosynthesis in moths have revealed that this function can be elicited by additional neuropeptides all of which share the common C-terminal pentapeptide FXPRL-amide (X = S, T, G, V). In the past two decades extensive studies were carried out on the chemical, cellular and molecular aspects of PBAN and the other peptides (termed the pyrokinin (PK)/PBAN family) aiming to understand the mode of their action on sex pheromone biosynthesis. In the present review we focus on a few of these aspects, specifically on the: (i) structure-activity relationship (SAR) of the PK/PBAN family, (ii) characterization of the PK/PBAN receptor and (iii) development of a novel strategy for the generation of PK/PBAN antagonists and their employment in studying the mode of action of the PK/PBAN peptides" |
| Keywords: | "Animals Female Gonadal Steroid Hormones/metabolism Male Models, Chemical Moths Neuropeptides/*chemistry Peptides/chemistry Protein Conformation Protein Structure, Tertiary Sex Attractants/*biosynthesis/*chemistry/physiology Structure-Activity Relationship;" |
| Notes: | "MedlineAltstein, Miriam eng Research Support, Non-U.S. Gov't Review 2004/09/18 Peptides. 2004 Sep; 25(9):1491-501. doi: 10.1016/j.peptides.2004.06.020" |
