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Neuron

Title:		Regulation of C. elegans longevity by specific gustatory and olfactory neurons
Author(s):		Alcedo J; Kenyon C;
Address:		"Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA"
Journal Title:		Neuron
Year:		2004
Volume:		41
Issue:		1
Page Number:		45 - 55
DOI:		10.1016/s0896-6273(03)00816-x
ISSN/ISBN:		0896-6273 (Print) 0896-6273 (Linking)
Abstract:		"The life span of C. elegans is extended by mutations that inhibit the function of sensory neurons. In this study, we show that specific subsets of sensory neurons influence longevity. We find that certain gustatory neurons inhibit longevity, whereas others promote longevity, most likely by influencing insulin/IGF-1 signaling. Olfactory neurons also influence life span, and they act in a distinct pathway that involves the reproductive system. In addition, we find that a putative chemosensory G protein-coupled receptor that is expressed in some of these sensory neurons inhibits longevity. Together our findings imply that the life span of C. elegans is regulated by environmental cues and that these cues are perceived and integrated in a complex and sophisticated fashion by specific chemosensory neurons"
Keywords:		"Animals Caenorhabditis elegans/*physiology Caenorhabditis elegans Proteins/physiology Denervation Fatty Acids/physiology Feeding Behavior/physiology GTP-Binding Protein alpha Subunits, Gi-Go/physiology Gonads/physiology Longevity/*physiology Membrane Prot;"
Notes:		"MedlineAlcedo, Joy Kenyon, Cynthia eng AG11816/AG/NIA NIH HHS/ F32 AG05860/AG/NIA NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 2004/01/13 Neuron. 2004 Jan 8; 41(1):45-55. doi: 10.1016/s0896-6273(03)00816-x"