| Title: | A simple method for estimating in vitro air-tissue and in vivo blood-tissue partition coefficients |
| Author(s): | Abraham MH; Gola JM; Ibrahim A; Acree WE; Liu X; |
| Address: | "Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK. Electronic address: ucca16a@ucl.ac.uk. Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK. Department of Chemistry, 1155 Union Circle Drive #305070, University of North Texas, Denton, TX 76203-5017, USA. School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK" |
| DOI: | 10.1016/j.chemosphere.2014.06.037 |
| ISSN/ISBN: | 1879-1298 (Electronic) 0045-6535 (Linking) |
| Abstract: | "A simple method is reported for the estimation of in vivo air-tissue partition coefficients of VOCs and of in vitro blood-tissue partition coefficients for volatile organic compounds and other compounds. Linear free energy relationships for tissues such as brain, muscle, liver, lung, kidney, heart, skin and fat are available and once the Abraham descriptors are known for a compound, no more than simple arithmetic is required to estimate air-tissue and blood-tissue partitions" |
| Keywords: | "Humans Models, Theoretical Pesticides/*pharmacokinetics Skin/*metabolism Skin Absorption Tissue Distribution Toxicology/*methods Abraham descriptors Air-tissue partition Blood-tissue partition Volatile organic compounds;" |
| Notes: | "MedlineAbraham, Michael H Gola, Joelle M R Ibrahim, Adam Acree, William E Jr Liu, Xiangli eng England 2014/07/20 Chemosphere. 2015 Feb; 120:188-91. doi: 10.1016/j.chemosphere.2014.06.037. Epub 2014 Jul 17" |
