| Title: | "Soybean isoflavone affects in rabbits: Effects on metabolism, antioxidant capacity, hormonal balance and reproductive performance" |
| Author(s): | Abo-Elsoud MA; Hashem NM; Nour El-Din ANM; Kamel KI; Hassan GA; |
| Address: | "Department of Animal and Fish Production, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria 21545, Egypt. Department of Animal and Fish Production, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria 21545, Egypt. Electronic address: nesreen.hashem@alexu.edu.eg. Rabbit and Waterfowl Breeding Department, Animal production Research Institute, Agricultural Research Center, Egypt" |
| DOI: | 10.1016/j.anireprosci.2019.02.007 |
| ISSN/ISBN: | 1873-2232 (Electronic) 0378-4320 (Linking) |
| Abstract: | "Though soybean isoflavones (SBI) have pharmaceutical properties, the compounds also have endocrine disrupting activities that may adversely affect fertility of mammals. The effects of SBI on metabolism, antioxidant capacity, hormonal balance and reproductive performance of male rabbits were investigated. Adult male rabbits (n = 21) fed an isoflavone-free diet were orally treated with 0 (control; CON), 5 (small; LSBI) or 20 (large; HSBI) mg of SBI/kg body weight/day for 12 weeks. Both SBI doses resulted in lesser blood plasma total protein concentrations, while there were no effects on glucose and cholesterol concentrations compared to CON. The HSBI-treated males had the greatest (P < 0.05) blood plasma total antioxidant capacity and least malondialdehyde. Treatment with both SBI doses induced a 43% increase in triiodothyronine concentrations (P < 0.05) and 82% in reaction times (P < 0.001), while decreased sperm concentrations (P = 0.01) and blood plasma testosterone concentrations (P = 0.017) 26% and 19%, respectively. The total functional sperm fraction was less (P < 0.05) in the HSBI group; however, there was no effect of the LSBI treatment as compared to values for the CON group. The kindling rates of females mated to HSBI-treated males tended to be less (P = 0.081) than those of does mated with LSBI or CON males. In conclusion, only the HSBI treatment improved antioxidant status; whereas, treatment with both LSBI and HSBI doses induced a hormonal imbalance which led to an impaired testis function indicating the sensitivity of the adult male reproductive system to SBI actions" |
| Keywords: | Animals Antioxidants/*pharmacology Female Fertility Isoflavones/*pharmacology Male Malondialdehyde/*metabolism Rabbits *Reproduction Semen/chemistry/cytology/*drug effects Soybeans/*chemistry Testosterone/*blood Blood metabolites Daidzein Genistein Males; |
| Notes: | "MedlineAbo-Elsoud, M A Hashem, N M Nour El-Din, A N M Kamel, K I Hassan, G A eng Netherlands 2019/03/02 Anim Reprod Sci. 2019 Apr; 203:52-60. doi: 10.1016/j.anireprosci.2019.02.007. Epub 2019 Feb 16" |
