| Title: | Neurobiology of TRPC2: from gene to behavior |
| Author(s): | Zufall F; Ukhanov K; Lucas P; Liman ER; Leinders-Zufall T; |
| Address: | "Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201-1509, USA. fzufa001@umaryland.edu" |
| DOI: | 10.1007/s00424-005-1432-4 |
| ISSN/ISBN: | 0031-6768 (Print) 0031-6768 (Linking) |
| Abstract: | "The mammalian vomeronasal organ (VNO), a part of the accessory olfactory system, plays an essential role in the sensing of pheromonal signals. The VNO has emerged as an excellent model to investigate the functional role of transient receptor potential (TRP) channels in intact neurons and intact physiological systems. TRPC2, a member of the (canonical) TRPC subfamily, is highly localized to the dendritic tip of vomeronasal sensory neurons. Phenotypic analysis of mice exhibiting a targeted deletion in the TRPC2 gene has established that TRPC2 occupies a fundamental role in the transduction machinery underlying the detection of pheromone signals by the VNO. TRPC2-deficient mice exhibit striking behavioral defects in the regulation of sexual and social behaviors. A previously unknown Ca(2+)-permeable, diacylglycerol (DAG)-activated cation channel found at the dendritic tip of vomeronasal neurons is severely defective in TRPC2 mutants, providing the first clear example for the existence of native DAG-gated cation channels in the mammalian nervous system. The experimental strategy employed in the mouse VNO now serves as a powerful model for examining the native functions of other TRP genes" |
| Keywords: | "Aggression/physiology Animals Behavior, Animal/physiology Diacylglycerol Kinase/metabolism Diglycerides/physiology Female Male Mice Olfactory Receptor Neurons/physiology Pheromones/physiology Rats Signal Transduction/physiology Smell/physiology TRPC Catio;neuroscience;" |
| Notes: | "MedlineZufall, Frank Ukhanov, Kyrill Lucas, Philippe Liman, E R Leinders-Zufall, Trese eng Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review Germany 2005/06/23 Pflugers Arch. 2005 Oct; 451(1):61-71. doi: 10.1007/s00424-005-1432-4. Epub 2005 Jun 22" |
