« Previous AbstractDisaccharides: Influence on Volatiles and Phenolics of Sour Cherry Juice    Next AbstractComparison of atmosphere/aquatic environment concentration ratio of volatile chlorinated hydrocarbons between temperate regions and Antarctica »

Molecules

Title:		"Chemical composition, biological and cytotoxic activities of plant extracts and compounds isolated from Ferula lutea"
Author(s):		Znati M; Hichem BJ; Cazaux S; Bouajila J;
Address:		"Laboratoire des IMRCP UMR CNRS 5623, Faculte de pharmacie de Toulouse, Universite de Toulouse, Universite Paul-Sabatier, 118 route de Narbonne, Toulouse F-31062, France. Laboratoire de Chimie Heterocyclique, Produits Naturels et Reactivite (CHPNR), Equipe Chimie Medicinale et Produits Naturels, Departement de Chimie, Faculte des Sciences de Monastir, Universite de Monastir, Avenue de l'Environnement, Monastir 5019, Tunisia. hichem.benjannet@yahoo.fr. Laboratoire des IMRCP UMR CNRS 5623, Faculte de pharmacie de Toulouse, Universite de Toulouse, Universite Paul-Sabatier, 118 route de Narbonne, Toulouse F-31062, France. jalloul.bouajila@univ-tlse3.fr"
Journal Title:		Molecules
Year:		2014
Volume:		20140226
Issue:		3
Page Number:		2733 - 2747
DOI:		10.3390/molecules19032733
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"The present work describes the phytochemical study on Ferula lutea flowers. Total phenolics and flavonoids of the n-butanol and ethyl acetate extracts were quantified (phenolics [40.68-52.29 mg gallic acid equivalent/g of dry weight], flavonoids [12.38-14.72 mg quercitin/g dry weight]). Two diastereoisomers were isolated and identified using spectroscopic techniques (1D, 2D NMR and GC-MS). The extracts and diastereoisomers were tested for antioxidant, antiacetylcholinesterase, antimicrobial, antidiabectic, cytotoxic (leukemia cell line) activities and allelopathic potentialities. The strongest antioxidant activity was obtained for the ethyl acetate extract (IC(5)(0) = 12.8 +/- 1.29 microg/mL). The two extracts exhibited high antidiabetic activity (54.1 and 52.1% at 40 microg/mL)"
Keywords:		"Anti-Infective Agents Antioxidants Cholinesterase Inhibitors Ferula/*chemistry Flavonoids/chemistry Hypoglycemic Agents Nuclear Magnetic Resonance, Biomolecular Phenols/chemistry Pheromones Plant Extracts/*chemistry/isolation & purification/*pharmacology/;"
Notes:		"MedlineZnati, Mansour Hichem, Ben Jannet Cazaux, Sylvie Bouajila, Jalloul eng Switzerland 2014/03/01 Molecules. 2014 Feb 26; 19(3):2733-47. doi: 10.3390/molecules19032733"