| Title: | Ascarosides coordinate the dispersal of a plant-parasitic nematode with the metamorphosis of its vector beetle |
| Author(s): | Zhao L; Zhang X; Wei Y; Zhou J; Zhang W; Qin P; Chinta S; Kong X; Liu Y; Yu H; Hu S; Zou Z; Butcher RA; Sun J; |
| Address: | "State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA. Department of Forestry, Northeast Forestry University, Haerbin 150040, China. The Research Institute of Forest Ecology, Environment and Protection, The Chinese Academy of Forestry, Beijing 100091, China. Forestry Academy of Jiangsu Province, Nanjing 211153, China. CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China" |
| ISSN/ISBN: | 2041-1723 (Electronic) 2041-1723 (Linking) |
| Abstract: | "Insect vectors are required for the transmission of many species of parasitic nematodes, but the mechanisms by which the vectors and nematodes coordinate their life cycles are poorly understood. Here, we report that ascarosides, an evolutionarily conserved family of nematode pheromones, are produced not only by a plant-parasitic nematode, but also by its vector beetle. The pinewood nematode and its vector beetle cause pine wilt disease, which threatens forest ecosystems world-wide. Ascarosides secreted by the dispersal third-stage nematode LIII larvae promote beetle pupation by inducing ecdysone production in the beetle and up-regulating ecdysone-dependent gene expression. Once the beetle develops into the adult stage, it secretes ascarosides that attract the dispersal fourth-stage nematode LIV larvae, potentially facilitating their movement into the beetle trachea for transport to the next pine tree. These results demonstrate that ascarosides play a key role in the survival and spread of pine wilt disease" |
| Keywords: | "Animals Biological Evolution Coleoptera/*parasitology/physiology Ecdysone/metabolism/physiology Female Forests Host-Parasite Interactions/physiology Insect Vectors/*physiology Larva/physiology Male Metamorphosis, Biological/*physiology Pheromones/metaboli;" |
| Notes: | "MedlineZhao, Lilin Zhang, Xinxing Wei, Yanan Zhou, Jiao Zhang, Wei Qin, Peijun Chinta, Satya Kong, Xiangbo Liu, Yunpeng Yu, Haiying Hu, Songnian Zou, Zhen Butcher, Rebecca A Sun, Jianghua eng Research Support, Non-U.S. Gov't England 2016/08/02 Nat Commun. 2016 Aug 1; 7:12341. doi: 10.1038/ncomms12341" |
