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Mol Cell Proteomics

Title:		The Neuroproteomic Basis of Enhanced Perception and Processing of Brood Signals That Trigger Increased Reproductive Investment in Honeybee (Apis mellifera) Workers
Author(s):		Zhang X; Hu H; Han B; Wei Q; Meng L; Wu F; Fang Y; Feng M; Ma C; Rueppell O; Li J;
Address:		"Institute of Apicultural Research/Key Laboratory of Pollinating Insect Biology, Ministry of Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China; Institute of Horticultural Research, Shanxi Academy of Agricultural Sciences, Shanxi Agricultural University, Taiyuan, China. Institute of Apicultural Research/Key Laboratory of Pollinating Insect Biology, Ministry of Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China. Department of Biology, University of North Carolina at Greensboro, Greensboro, North Carolina, USA. Electronic address: olav_rueppell@uncg.edu. Institute of Apicultural Research/Key Laboratory of Pollinating Insect Biology, Ministry of Agriculture, Chinese Academy of Agricultural Sciences, Beijing, China. Electronic address: apislijk@126.com"
Journal Title:		Mol Cell Proteomics
Year:		2020
Volume:		20200715
Issue:		10
Page Number:		1632 - 1648
DOI:		10.1074/mcp.RA120.002123
ISSN/ISBN:		1535-9484 (Electronic) 1535-9476 (Print) 1535-9476 (Linking)
Abstract:		"The neuronal basis of complex social behavior is still poorly understood. In honeybees, reproductive investment decisions are made at the colony-level. Queens develop from female-destined larvae that receive alloparental care from nurse bees in the form of ad-libitum royal jelly (RJ) secretions. Typically, the number of raised new queens is limited but genetic breeding of 'royal jelly bees' (RJBs) for enhanced RJ production over decades has led to a dramatic increase of reproductive investment in queens. Here, we compare RJBs to unselected Italian bees (ITBs) to investigate how their cognitive processing of larval signals in the mushroom bodies (MBs) and antennal lobes (ALs) may contribute to their behavioral differences. A cross-fostering experiment confirms that the RJB syndrome is mainly due to a shift in nurse bee alloparental care behavior. Using olfactory conditioning of the proboscis extension reflex, we show that the RJB nurses spontaneously respond more often to larval odors compared with ITB nurses but their subsequent learning occurs at similar rates. These phenotypic findings are corroborated by our demonstration that the proteome of the brain, particularly of the ALs differs between RJBs and ITBs. Notably, in the ALs of RJB newly emerged bees and nurses compared with ITBs, processes of energy and nutrient metabolism, signal transduction are up-regulated, priming the ALs for receiving and processing the brood signals from the antennae. Moreover, highly abundant major royal jelly proteins and hexamerins in RJBs compared with ITBs during early life when the nervous system still develops suggest crucial new neurobiological roles for these well-characterized proteins. Altogether, our findings reveal that RJBs have evolved a strong olfactory response to larvae, enabled by numerous neurophysiological adaptations that increase the nurse bees' alloparental care behavior"
Keywords:		"Animals Arthropod Antennae/anatomy & histology Bees/anatomy & histology/*physiology *Hierarchy, Social Insect Proteins/metabolism Larva/metabolism Mushroom Bodies/metabolism *Perception Pheromones/metabolism *Proteomics Reproduction/physiology Apis mellif;"
Notes:		"MedlineZhang, Xufeng Hu, Han Han, Bin Wei, Qiaohong Meng, Lifeng Wu, Fan Fang, Yu Feng, Mao Ma, Chuan Rueppell, Olav Li, Jianke eng Research Support, Non-U.S. Gov't 2020/07/17 Mol Cell Proteomics. 2020 Oct; 19(10):1632-1648. doi: 10.1074/mcp.RA120.002123. Epub 2020 Jul 15"