| Title: | Usefulness of toxicological validation of VOCs catalytic degradation by air-liquid interface exposure system |
| Author(s): | Al Zallouha M; Landkocz Y; Brunet J; Cousin R; Genty E; Courcot D; Siffert S; Shirali P; Billet S; |
| Address: | "Unite de Chimie Environnementale et Interactions sur le Vivant EA4492, Universite du Littoral Cote d'Opale, 189A Avenue Maurice Schumann, 59140 Dunkerque, France. Unite de Chimie Environnementale et Interactions sur le Vivant EA4492, Universite du Littoral Cote d'Opale, 189A Avenue Maurice Schumann, 59140 Dunkerque, France. Electronic address: Sylvain.Billet@univ-littoral.fr" |
| DOI: | 10.1016/j.envres.2016.10.027 |
| ISSN/ISBN: | 1096-0953 (Electronic) 0013-9351 (Linking) |
| Abstract: | "Toluene is one of the most used Volatile Organic Compounds (VOCs) in the industry despite its major health impacts. Catalytic oxidation represents an efficient remediation technique in order to reduce its emission directly at the source, but it can release by-products. To complete the classical performance assessment using dedicated analytical chemistry methods, we propose to perform an untargeted toxicological validation on two efficient catalysts. Using biological system allows integrating synergy and antagonism in toxic effects of emitted VOCs and by-products, often described in case of multi-exposure condition. Catalysts Pd/alpha-Al(2)O(3) and Pd/gamma-Al(2)O(3) developed for the oxidation of toluene were both coupled to a Vitrocell((R)) Air-Liquid Interface (ALI) system, for exposure of human A549 lung cells during 1h to toluene or to catalysts exhaust before quantification of xenobiotics metabolizing enzymes. This study validated initially the Vitrocell((R)) as an innovative, direct and dynamic model of ALI exposure in the assessment of the performances of new catalysts, showing the presence of chemically undetected by-products. The comparison of the two catalysts showed then that fewer organic compounds metabolizing genes were induced by Pd/gamma-Al(2)O(3) in comparison to Pd/alpha-Al(2)O(3), suggesting that Pd/gamma-Al(2)O(3) is more efficient for toluene total oxidation from a toxicological point of view" |
| Keywords: | Aluminum Oxide/*chemistry *Catalysis Environmental Pollutants/*chemistry Environmental Restoration and Remediation/instrumentation/*methods Oxidation-Reduction Palladium/*chemistry Toluene/*chemistry Volatile Organic Compounds/chemistry Air-liquid interfa; |
| Notes: | "MedlineAl Zallouha, Margueritta Landkocz, Yann Brunet, Julien Cousin, Renaud Genty, Eric Courcot, Dominique Siffert, Stephane Shirali, Pirouz Billet, Sylvain eng Validation Study Netherlands 2016/11/13 Environ Res. 2017 Jan; 152:328-335. doi: 10.1016/j.envres.2016.10.027. Epub 2016 Nov 9" |
