« Previous Abstract"Motivation, Perception, and Chance Converge to Make a Binary Decision"    Next AbstractConstruction and analysis of cDNA libraries from the antennae of male and female cotton bollworms Helicoverpa armigera (Hubner) and expression analysis of putative odorant-binding protein genes »

Open Biol

Title:		Cell cycle commitment in budding yeast emerges from the cooperation of multiple bistable switches
Author(s):		Zhang T; Schmierer B; Novak B;
Address:		"Oxford Centre for Integrative Systems Biology (OCISB), Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK"
Journal Title:		Open Biol
Year:		2011
Volume:		1
Issue:		3
Page Number:		110009 -
DOI:		10.1098/rsob.110009
ISSN/ISBN:		2046-2441 (Electronic) 2046-2441 (Linking)
Abstract:		"The start-transition (START) in the G1 phase marks the point in the cell cycle at which a yeast cell initiates a new round of cell division. Once made, this decision is irreversible and the cell is committed to progressing through the entire cell cycle, irrespective of arrest signals such as pheromone. How commitment emerges from the underlying molecular interaction network is poorly understood. Here, we perform a dynamical systems analysis of an established cell cycle model, which has never been analysed from a commitment perspective. We show that the irreversibility of the START transition and subsequent commitment can be consistently explained in terms of the interplay of multiple bistable molecular switches. By applying an existing mathematical model to a novel problem and by expanding the model in a self-consistent manner, we achieve several goals: we bring together a large number of experimental findings into a coherent theoretical framework; we increase the scope and the applicability of the original model; we give a systems level explanation of how the START transition and the cell cycle commitment arise from the dynamical features of the underlying molecular interaction network; and we make clear, experimentally testable predictions"
Keywords:		"Adaptor Proteins, Signal Transducing/genetics/metabolism CDC2 Protein Kinase/genetics/metabolism Cell Cycle/drug effects/genetics/*physiology Cyclin-Dependent Kinase Inhibitor Proteins/genetics/metabolism Cyclins/genetics/metabolism Feedback, Physiologica;"
Notes:		"MedlineZhang, Tongli Schmierer, Bernhard Novak, Bela eng Research Support, Non-U.S. Gov't England 2012/05/31 Open Biol. 2011 Nov; 1(3):110009. doi: 10.1098/rsob.110009"