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J Am Chem Soc

Title:		Me2(CH2Cl)SiCN: Bifunctional Cyanating Reagent for the Synthesis of Tertiary Alcohols with a Chloromethyl Ketone Moiety via Ketone Cyanosilylation
Author(s):		Zeng XP; Zhou J;
Address:		"Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University , 3663N Zhongshan Road, Shanghai 200062, China. State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin 300071, P. R. China"
Journal Title:		J Am Chem Soc
Year:		2016
Volume:		20160711
Issue:		28
Page Number:		8730 - 8733
DOI:		10.1021/jacs.6b05601
ISSN/ISBN:		1520-5126 (Electronic) 0002-7863 (Linking)
Abstract:		"We report a novel bifunctional cyanating reagent, Me2(CH2Cl)SiCN, which paves the way to a one-pot sequential synthesis of tertiary alcohols featuring a chloromethyl ketone moiety via enantioselective ketone cyanosilylation. This method contributes to gram-scale enantioselective total synthesis of the aggregation pheromone of the Colorado potato beetle, (S)-CPB"
Keywords:
Notes:		"PubMed-not-MEDLINEZeng, Xing-Ping Zhou, Jian eng Research Support, Non-U.S. Gov't 2016/07/12 J Am Chem Soc. 2016 Jul 20; 138(28):8730-3. doi: 10.1021/jacs.6b05601. Epub 2016 Jul 11"