| Title: | Analysis of multi-omics data on the relationship between epigenetic changes and nervous system disorders caused by exposure to environmentally harmful substances |
| Author(s): | Yu SY; Koh EJ; Kim SH; Song B; Lee JS; Son SW; Seo H; Hwang SY; |
| Address: | "Department of Molecular & Life Science, Hanyang University, Ansan, South Korea. Department of Bionano Engineering, Hanyang University, Ansan, South Korea. Department of Molecular & Life Sciences, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, South Korea. Department of Dermatology, Korea University College of Medicine, Seoul, South Korea. Department of Applied Artificial Intelligence, Hanyang University, Ansan, South Korea" |
| ISSN/ISBN: | 1522-7278 (Electronic) 1520-4081 (Linking) |
| Abstract: | "Environmentally hazardous substances and exposure to these can cause various diseases. Volatile organic compounds can easily evaporate into the atmosphere, thereby exerting toxic effects through either the skin or respiratory tract exposures. Toluene, a neurotoxin, has been widely used in various industries. However, it has a detrimental effect on the nervous system (such as hallucinations or memory impairment), while data on the mechanism underlaying its harmful effects remain limited. Therefore, this study investigates the effect of toluene on the nervous system via epigenetic and genetic changes of toluene-exposed individuals. We identified significant epigenetic changes and confirmed that the affected abnormally expressed genes negatively influenced the nervous system. In particular, we confirmed that the miR-15 family, upregulated by toluene, downregulated ABL2, which could affect the R as signaling pathway resulting in neuronal structural abnormalities. Our study suggests that miR-15a-5p, miR-15b-5p, miR-16-5p, miR-301a-3p, and lncRNA NEAT1 may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene" |
| Keywords: | "Epigenesis, Genetic Humans *MicroRNAs/genetics/metabolism *Nervous System Diseases/genetics *RNA, Long Noncoding/genetics Signal Transduction Ras signaling epigenetic neurodegenerative diseases noncoding RNA toluene;" |
| Notes: | "MedlineYu, So Yeon Koh, Eun Jung Kim, Seung Hwan Song, Byeongwook Lee, Ji Su Son, Sang Wook Seo, Hyemyung Hwang, Seung Yong eng 2017001360005/Korea Ministry of Environment/ 2021/12/19 Environ Toxicol. 2022 Apr; 37(4):802-813. doi: 10.1002/tox.23444. Epub 2021 Dec 18" |
